Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients
DC Field | Value | Language |
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dc.contributor.author | Park, Jong-Sook | - |
dc.contributor.author | Heo, Jeong-Seok | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Choi, Inseon S. | - |
dc.contributor.author | Kim, Mi-Kyeong | - |
dc.contributor.author | Lee, Jong-Uk | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.date.accessioned | 2021-08-11T23:24:31Z | - |
dc.date.available | 2021-08-11T23:24:31Z | - |
dc.date.issued | 2014-03-01 | - |
dc.identifier.issn | 1044-5498 | - |
dc.identifier.issn | 1557-7430 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12340 | - |
dc.description.abstract | Member RAS oncogene family (RAB1A), a member of the RAS oncogene family, cycles between inactive GDP-bound and active GTP-bound forms regulating vesicle transport in exocytosis. Thus, functional alterations of the RAB1A gene may contribute to aspirin intolerance in asthmatic sufferers. To investigate the relationship between single-nucleotide polymorphisms (SNPs) in the RAB1A gene and aspirin-exacerbated respiratory disease (AERD), asthmatics (n=1197) were categorized into AERD and aspirin-tolerant asthma (ATA). All subjects were diagnosed as asthma on the basis of the Global Initiative for Asthma (GINA) guidelines. AERD was defined as asthmatics showing 15% or greater decreases in forced expiratory volume in one second (FEV1) or naso-ocular reactions by the oral acetyl salicylic acid (ASA) challenge (OAC) test. In total, eight SNPs were genotyped. Logistic regression analysis identified that the minor allele frequency of +14444 T>G and +41170 C>G was significantly higher in the AERD group (n=181) than in the ATA group (n=1016) (p=0.0003-0.03). Linear regression analysis revealed a strong association between the SNPs and the aspirin-induced decrease in FEV1 (p=0.0004-0.004). The RAB1A gene may play a role in the development of AERD in asthmatics and the genetic polymorphisms of the gene have the potential to be used as an indicator of this disease. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1089/dna.2013.2213 | - |
dc.identifier.scopusid | 2-s2.0-84895745380 | - |
dc.identifier.wosid | 000332158600006 | - |
dc.identifier.bibliographicCitation | DNA and Cell Biology, v.33, no.3, pp 155 - 161 | - |
dc.citation.title | DNA and Cell Biology | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 161 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | EXACERBATED RESPIRATORY-DISEASE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | RAP1B | - |
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