Pretreatment with recombinant human interleukin 2 (rhIL-2) Up-regulates PCNA-positive cells after partial hepatectomy in rat liver
DC Field | Value | Language |
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dc.contributor.author | Jeon, Miae | - |
dc.contributor.author | Kwon, Hyun Jung | - |
dc.contributor.author | Kim, Yong Hyun | - |
dc.contributor.author | Han, Kook-Il | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Baik, Yeongjun | - |
dc.contributor.author | Lee, Sunghee | - |
dc.contributor.author | Kim, Wan-Jong | - |
dc.contributor.author | Han, Man-Deuk | - |
dc.date.accessioned | 2021-08-11T23:25:37Z | - |
dc.date.available | 2021-08-11T23:25:37Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.issn | 1976-3816 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12450 | - |
dc.description.abstract | We prepared recombinant human interleukin-2 (rhIL-2) and studied its pretreated influence on liver regeneration and the blood profile in partially (67%) hepatectomized (PH) male Sprague-Dawley rats. Rats were injected in the tail vein with rhIL-2 three times per day for 3 consecutive days and 67% underwent a partial hepatectomy (PH). Five days after the PH, liver tissue and blood samples were analyzed for liver regeneration and hematological changes. The weight of the liver in the rhIL-2 pretreated groups increased in a dose-dependent manner; with the highest treatment (24 x 10(4) IU/kg), the maximum liver weight of 88.6% was exhibited. The control group showed a gradual increase to 76.3% of the original liver weight. A histological analysis of the liver showed an increase in proliferating cell nuclear antigen (PCNA)-positive cells in rhIL-2 pretreated rat livers. The rate of hepatocyte proliferation also increased significantly in primary cultured rat liver cells following rhIL-2 treatment. These results suggest that pretreatment with rhIL-2 may play adjuvant roles in liver regeneration after PH. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국생물공학회 | - |
dc.title | Pretreatment with recombinant human interleukin 2 (rhIL-2) Up-regulates PCNA-positive cells after partial hepatectomy in rat liver | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12257-013-0667-8 | - |
dc.identifier.scopusid | 2-s2.0-84896985748 | - |
dc.identifier.wosid | 000333012300006 | - |
dc.identifier.bibliographicCitation | Biotechnology and Bioprocess Engineering, v.19, no.1, pp 43 - 51 | - |
dc.citation.title | Biotechnology and Bioprocess Engineering | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 51 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001855702 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IL-2 | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordAuthor | rhIL-2 | - |
dc.subject.keywordAuthor | partial hepatectomy (PH) | - |
dc.subject.keywordAuthor | PCNA | - |
dc.subject.keywordAuthor | immunohistochemistry | - |
dc.subject.keywordAuthor | liver regeneration | - |
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