Prognostic factors for post-recurrence survival in patients with completely resected Stage I non-small-cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Song, In Hag | - |
dc.contributor.author | Yeom, Sung Won | - |
dc.contributor.author | Heo, Seohee | - |
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Yang, Hee Chul | - |
dc.contributor.author | Jheon, Sanghoon | - |
dc.contributor.author | Kim, Kwhanmien | - |
dc.contributor.author | Cho, Sukki | - |
dc.date.accessioned | 2021-08-11T23:25:56Z | - |
dc.date.available | 2021-08-11T23:25:56Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1010-7940 | - |
dc.identifier.issn | 1873-734X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12470 | - |
dc.description.abstract | The clinical course from recurrence to cancer-related death after curative resection has not been clearly elucidated in non-small-cell lung cancer (NSCLC). This study examined the clinical outcomes after postoperative recurrence in patients with completely resected Stage I NSCLC. This study included patients who had recurrence after complete resection for pathological Stage I NSCLC between 2003 and 2009. Clinical data evaluated in this study included the diagnostic process of recurrence, recurrence pattern, treatment process and prognosis. A number of clinicopathological factors were analysed for post-recurrence survival by univariate and multivariate analyses. Seventy-two patients experienced recurrence during a median follow-up period of 37.5 months. Thirteen patients (18%) presented symptoms at the initial recurrence. Tumour markers, computed tomography (CT) and positron emission tomography/CT were chosen as the initial diagnostic tools and detected recurrences in 1 (1%), 51 (71%) and 7 (10%) patients, respectively. The mean recurrence-free interval (RFI) was 15.4 months (< 12 months in 34, > 12 months in 38 patients). The patterns of recurrence were presented as loco-regional recurrence in 36 (50%) and distant metastasis in 36 patients (50%). Types of the initial treatment included operations in 28 (39%), chemotherapy and/or radiotherapy in 38 (53%) and radiofrequency ablation in 2 patients (3%). Four patients (6%) rejected treatment. Forty-three patients (62%) presented a good response to the initial treatment. Thirty-seven patients (51%) died, and the cause of death in all of these patients was cancer-related. The median survival duration after recurrence was 43.6 (1-136) months. Univariate analysis identified no recurrence of symptoms, a good response to treatment and a longer RFI as good prognostic factors, while a good response to treatment and a longer RFI were independent prognostic factors in multivariate analysis. Most postoperative recurrences were detected in an asymptomatic condition during the routine follow-up period, and a good response to initial treatment and a longer RFI were significant predictors of better post-recurrence survival in patients with completely resected Stage I NSCLC. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Prognostic factors for post-recurrence survival in patients with completely resected Stage I non-small-cell lung cancer | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1093/ejcts/ezt333 | - |
dc.identifier.scopusid | 2-s2.0-84892501859 | - |
dc.identifier.wosid | 000330438700018 | - |
dc.identifier.bibliographicCitation | European Journal of Cardio-thoracic Surgery, v.45, no.2, pp 262 - 267 | - |
dc.citation.title | European Journal of Cardio-thoracic Surgery | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 262 | - |
dc.citation.endPage | 267 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | POSTRECURRENCE SURVIVAL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | LOCAL RECURRENCE | - |
dc.subject.keywordPlus | TOMOGRAPHY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Non-small-cell lung cancer | - |
dc.subject.keywordAuthor | Stage I | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Post-recurrence survival | - |
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