비스테로이드성 소염제 사용자에서의 헬리코박터 파일로리 감염Helicobacter pylori Infection in Nonsteroidal Anti-inflammatory Drug Users
- Other Titles
- Helicobacter pylori Infection in Nonsteroidal Anti-inflammatory Drug Users
- Authors
- 임윤정; 홍수진
- Issue Date
- 2014
- Publisher
- 대한소화기학회
- Keywords
- Anti-inflammatory agents; non-steroidal; Helicobacter pylori; Peptic ulcer
- Citation
- 대한소화기학회지, v.64, no.2, pp 70 - 75
- Pages
- 6
- Journal Title
- 대한소화기학회지
- Volume
- 64
- Number
- 2
- Start Page
- 70
- End Page
- 75
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12799
- ISSN
- 1598-9992
2233-6869
- Abstract
- NSAID-induced upper gastrointestinal (GI) damage occurs easily in people with a prior history of complicated or uncomplicated ulcers. Many recent clinical studies have proved the benefit of Helicobacter pylori eradication in NSAID users; however, the exact pathophysiologic relationship between concomitant H. pylori infection and NSAID use has not yet been fully elucidated. Testing and eradication of H. pylori are generally recommended in patients who are at a high risk for NSAID-induced GI damage. However, in high-risk patients, ulcer prophylaxis with proton pump inhibitor or misoprostol is needed even if H. pylori has been successfully eradicated. In low-risk patients, it is still questionable whether or not eradication of H. pylori can reduce upper GI damage. However, in western countries, due to its cost effectiveness, testing and eradication of H. pylori is recommended before starting aspirin or NSAID irrespective of the risk level. In regions with a high prevalence of H. pylori infection (>20%), the usefulness of testing and eradication of H. pylori has not yet been determined.
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