Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer
DC Field | Value | Language |
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dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Baek, Ji Yeon | - |
dc.contributor.author | Chang, Hee Jin | - |
dc.contributor.author | Park, Ji Won | - |
dc.contributor.author | Oh, Jae Hwan | - |
dc.date.accessioned | 2021-08-12T00:25:04Z | - |
dc.date.available | 2021-08-12T00:25:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1513-7368 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13019 | - |
dc.description.abstract | Purpose: To investigate whether pretreatment serum carbohydrate antigen 19-9 (CA 19-9) levels are associated with pathological responses to preoperative chemoradiotherapy (CRT) in patients with rectal cancer. Materials and Methods: In total, 260 patients with locally advanced rectal cancer (cT3-4NanyM0) who underwent preoperative CRT and radical surgery were analyzed retrospectively. CRT consisted of 50.4 Gy pelvic radiotherapy and concurrent chemotherapy. Radical surgery was performed at a median of 7 weeks after CRT completion. Pathological CRT response criteria included downstaging (ypStage 0-I) and ypT0-1. A discrimination threshold of CA 19-9 level was determined using a receiver operating characteristics analysis. Results: The median CA 19-9 level was 8.0 (1.0-648.0) U/mL. Downstaging occurred in 94 (36.2%) patients and ypT0-1 in 50 (19.2%). The calculated optimal threshold CA 19-9 level was 10.2 U/mL for downstaging and 9.0 U/mL for ypT0-1. On multivariate analysis, CA 19-9 (<= 9.0 U/mL) was significantly associated with downstaging (odds ratio, 2.089; 95% confidence interval, 1.189-3.669; P=0.010) or ypT0-1 (OR, 2.207; 95% CI, 1.079-4.512; P=0.030), independent of clinical stage or carcinoembryonic antigen. Conclusions: This study firstly showed a significant association of pretreatment serum CA 19-9 levels with pathological CRT responses of rectal cancer. The CA 19-9 level is suggested to be valuable in predicting CRT responses of rectal cancer cases before treatment. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Asian Pacific Organization for Cancer Prevention | - |
dc.title | Carbohydrate Antigen 19-9 Levels Associated with Pathological Responses to Preoperative Chemoradiotherapy in Rectal Cancer | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.7314/APJCP.2014.15.13.5383 | - |
dc.identifier.scopusid | 2-s2.0-84905396716 | - |
dc.identifier.wosid | 000343722900048 | - |
dc.identifier.bibliographicCitation | Asian Pacific Journal of Cancer Prevention, v.15, no.13, pp 5383 - 5387 | - |
dc.citation.title | Asian Pacific Journal of Cancer Prevention | - |
dc.citation.volume | 15 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 5383 | - |
dc.citation.endPage | 5387 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TOTAL MESORECTAL EXCISION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | LOCAL EXCISION | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMORADIATION | - |
dc.subject.keywordPlus | CARCINOEMBRYONIC ANTIGEN | - |
dc.subject.keywordPlus | TUMOR RESPONSE | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | CEA | - |
dc.subject.keywordPlus | RADIOCHEMOTHERAPY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | CA 19-9 | - |
dc.subject.keywordAuthor | chemoradiotherapy | - |
dc.subject.keywordAuthor | response prediction | - |
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