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A Highly Facile and Specific Assay for Cancer-Causing Isocitrate Dehydrogenase Mutant Using C-13(4)-Labeled alpha-Ketoglutarate and Heteronuclear NMR
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wen, He | - |
| dc.contributor.author | Yun, Taeho | - |
| dc.contributor.author | Xu, Wen Jun | - |
| dc.contributor.author | Choi, Seung Hong | - |
| dc.contributor.author | Kim, Hyeonjin | - |
| dc.contributor.author | Park, Chul-Kee | - |
| dc.contributor.author | Lee, Se-Hoon | - |
| dc.contributor.author | Park, Sung-woo | - |
| dc.contributor.author | Lee, Sang Kook | - |
| dc.contributor.author | Park, Sunghyouk | - |
| dc.date.accessioned | 2021-08-12T00:25:28Z | - |
| dc.date.available | 2021-08-12T00:25:28Z | - |
| dc.date.issued | 2013-12-17 | - |
| dc.identifier.issn | 0003-2700 | - |
| dc.identifier.issn | 1520-6882 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13050 | - |
| dc.description.abstract | Isocitrate dehydrogenase mutations with neomorphic activity of converting a-ketoglutarate to 2-hydroxyglutarate have been found in many types of cancers. We report an NMR-based assay specific for the mutant using C-13(4)-labeled alpha-ketoglutarate. It can be done in a complex mixture without extraction, give time-dependent absolute quantitation, and be applied to enzyme inhibition studies. Its merits over conventional assays should facilitate inhibitor developments for a new class of target-oriented anticancer agents. | - |
| dc.format.extent | 6 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | American Chemical Society | - |
| dc.title | A Highly Facile and Specific Assay for Cancer-Causing Isocitrate Dehydrogenase Mutant Using C-13(4)-Labeled alpha-Ketoglutarate and Heteronuclear NMR | - |
| dc.type | Article | - |
| dc.publisher.location | 미국 | - |
| dc.identifier.doi | 10.1021/ac402947a | - |
| dc.identifier.scopusid | 2-s2.0-84890528982 | - |
| dc.identifier.wosid | 000328797200044 | - |
| dc.identifier.bibliographicCitation | Analytical Chemistry, v.85, no.24, pp 11987 - 11992 | - |
| dc.citation.title | Analytical Chemistry | - |
| dc.citation.volume | 85 | - |
| dc.citation.number | 24 | - |
| dc.citation.startPage | 11987 | - |
| dc.citation.endPage | 11992 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
| dc.subject.keywordPlus | IDH1 | - |
| dc.subject.keywordPlus | GLIOMAS | - |
| dc.subject.keywordPlus | MUTATIONS | - |
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Related Researcher
- Park, Sung woo
- College of Medicine (Department of Internal Medicine)