High insulin-like growth factor-1 in patients with bipolar I disorder: A trait marker?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.contributor.author | Hwang, Jung-A | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Hahn, Sang-Woo | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Jung, Han-Yong | - |
dc.date.accessioned | 2021-08-12T00:44:59Z | - |
dc.date.available | 2021-08-12T00:44:59Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.issn | 1573-2517 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13271 | - |
dc.description.abstract | Objectives: Neurotrophic factors exert substantial effects on the central nervous system. The present study investigates the roles of insulin-like growth factor-1 (IGF-1), beta-nerve growth factor (beta-NGF), and brain-derived neurotrophic factor (BDNF) in bipolar disorder. Methods: Baseline levels of culture-stimulated IGF-1, beta-NGF, and BDNF were compared in 116 patients with bipolar l disorder and 123 healthy controls. Neurotrophic factors were also compared in patients before and after 6 weeks of pharmacotherapy. A multivariate logistic regression analysis was used to investigate the influence of the neurotrophic factors analyzed in quartile form, in relation to confounding variables, such as age, sex, and body mass index. Results: IGF-1 was significantly higher in patients (mean=514.57, SD=259.78) than in healthy controls (mean=316.82, SD=270.00, p < 0.0001) at baseline. Furthermore, higher levels of IGF-1 substantially increased the risk for bipolar l disorder. IGF-1 level was not significantly changed at 6-weeks (mean=506.41, SD=313.66). No changes in BDNF or beta-NGF-1 levels were found following the 6-week treatment period. IGF-1 and beta-NGF were negatively correlated in healthy controls, but not in patients. Severity of manic symptoms was not associated with any of the neurotrophic factors. Limitations: We did not measure cortisol, growth hormone, or IGF-1 receptors. This study is cross-sectional in design. Conclusions: Elevated IGF-1 levels may be a trait marker for bipolar disorder. Further studies are needed to thoroughly investigate the role of IGF-1 in relation to other neuroendocrine factors and biological markers for bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | High insulin-like growth factor-1 in patients with bipolar I disorder: A trait marker? | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jad.2013.07.041 | - |
dc.identifier.scopusid | 2-s2.0-84885456040 | - |
dc.identifier.wosid | 000325432900045 | - |
dc.identifier.bibliographicCitation | Journal of Affective Disorders, v.151, no.2, pp 738 - 743 | - |
dc.citation.title | Journal of Affective Disorders | - |
dc.citation.volume | 151 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 738 | - |
dc.citation.endPage | 743 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | IGF-1 | - |
dc.subject.keywordPlus | BDNF | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | LITHIUM | - |
dc.subject.keywordPlus | NGF | - |
dc.subject.keywordAuthor | Bipolar disorder | - |
dc.subject.keywordAuthor | Insulin-like growth factor-1 | - |
dc.subject.keywordAuthor | Nerve growth factor | - |
dc.subject.keywordAuthor | Brain-derived neurotrophic factor | - |
dc.subject.keywordAuthor | Neurotrophin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.