Oncogenic function of p34(SEI-1) via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
DC Field | Value | Language |
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dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Li, Chengping | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.contributor.author | Lee, Soonduck | - |
dc.contributor.author | Ohk, Jiyeon | - |
dc.contributor.author | Park, Meeyoung | - |
dc.contributor.author | Han, Songyi | - |
dc.contributor.author | Duan, Jingjing | - |
dc.contributor.author | Kim, Changjin | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Kim, Keun-Il | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.contributor.author | Kang, Young-Sook | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.accessioned | 2021-08-12T00:45:01Z | - |
dc.date.available | 2021-08-12T00:45:01Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.issn | 1791-2423 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13274 | - |
dc.description.abstract | A 34-KD protein encoded by the SEI-1 gene (p34(SEI-1)), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34(SEI-1) enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34(SEI-1) positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34(SEI-1) and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34(SEI-1) affects the subcellular localization of PTEN. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Oncogenic function of p34(SEI-1) via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/ijo.2013.2064 | - |
dc.identifier.scopusid | 2-s2.0-84885048125 | - |
dc.identifier.wosid | 000324982700030 | - |
dc.identifier.bibliographicCitation | International Journal of Oncology, v.43, no.5, pp 1587 - 1595 | - |
dc.citation.title | International Journal of Oncology | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1587 | - |
dc.citation.endPage | 1595 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE NEDD4-1 | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | PI3K-AKT-MTOR PATHWAY | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INSTABILITY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordAuthor | 34-KD protein encoding selected with Ink4a-1 as bait gene | - |
dc.subject.keywordAuthor | phosphatase and tensin homolog deleted on chromosome ten | - |
dc.subject.keywordAuthor | neuronal precursor cell-expressed developmentally downregulated 4-1 | - |
dc.subject.keywordAuthor | phosphoinositide-3 kinase/protein kinase B | - |
dc.subject.keywordAuthor | tumorigenesis | - |
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