Prediction of risk for symptomatic sialadenitis by post-therapeutic dual I-131 scintigraphy in patients with differentiated thyroid cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Mi | - |
dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Kim, Shin Young | - |
dc.contributor.author | Han, Seon Wook | - |
dc.contributor.author | Bae, Won Kyoung | - |
dc.date.accessioned | 2021-08-12T00:45:37Z | - |
dc.date.available | 2021-08-12T00:45:37Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0914-7187 | - |
dc.identifier.issn | 1864-6433 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13322 | - |
dc.description.abstract | The aim of this study is to predict the risk of symptomatic sialadenitis after I-131 therapy using the early (third day post-therapy) and delayed (fifth or sixth day post-therapy) post-therapeutic I-131 scintigraphy images in patients with differentiated thyroid cancer (DTC). Included in the study were 112 patients with DTC who underwent early and delayed I-131 scans after I-131 treatment. All patients had normal salivary gland function on salivary scintigraphy performed in the week before the I-131 treatment. Scintigraphy images were visually analyzed and the salivary gland-to-background uptake ratio (SUR) and percent change of the SUR between early and delayed scans were calculated. Calculation of effective half-life and absorbed dose in the salivary glands was performed based on the MIRD schema. Of 112 patients, symptomatic sialadenitis was diagnosed in 46 patients (41 %). Of these 46 patients, 83 % (38 patients) had persistent I-131 uptake in the salivary glands on both early and delayed scans. Among 55 patients with persistent I-131 uptake in the salivary glands, 69 % experienced symptomatic sialadenitis, while only 14 % of the other 57 patients experienced symptomatic sialadenitis (p < 0.0001). On the early I-131 scintigraphy, SURs of bilateral parotid glands on early scan in patients with symptomatic sialadenitis were significantly higher than in other patients (p = 0.001 for right and p = 0.004 for left). Further, patients with symptomatic sialadenitis had a higher decreasing rate of the SUR and shorter effective half-life of I-131 in bilateral parotid glands than other patients. Using visual analysis and SURs of right and left parotid glands on early I-131 scan as parameters, the sensitivities for predicting symptomatic sialadenitis were 83, 80, and 93 %, respectively. The mean values of effective half-life and absorbed dose in the parotid and submandibular glands were 20.8 +/- A 6.3 h and 2.7 +/- A 0.8 Gy, and 22.1 +/- A 7.9 h and 2.8 +/- A 1.1 Gy, respectively. Symptomatic sialadenitis can be predicted by post-therapeutic I-131 scintigraphy with high sensitivity. Post-therapeutic I-131 scintigraphy could provide effective information on the risk of symptomatic sialadenitis in DTC patients who underwent I-131 treatment. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Japanese Society of Nuclear Medicine/Nihon Kaku Igakkai | - |
dc.title | Prediction of risk for symptomatic sialadenitis by post-therapeutic dual I-131 scintigraphy in patients with differentiated thyroid cancer | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s12149-013-0735-3 | - |
dc.identifier.scopusid | 2-s2.0-84886398595 | - |
dc.identifier.wosid | 000325822700003 | - |
dc.identifier.bibliographicCitation | Annals of Nuclear Medicine, v.27, no.8, pp 700 - 709 | - |
dc.citation.title | Annals of Nuclear Medicine | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 700 | - |
dc.citation.endPage | 709 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | SALIVARY-GLAND DYSFUNCTION | - |
dc.subject.keywordPlus | RADIOIODINE THERAPY | - |
dc.subject.keywordPlus | ACINAR-CELLS | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | IODINE | - |
dc.subject.keywordAuthor | Thyroid cancer | - |
dc.subject.keywordAuthor | Iodine-131 | - |
dc.subject.keywordAuthor | Salivary gland | - |
dc.subject.keywordAuthor | Sialadenitis | - |
dc.subject.keywordAuthor | Post-therapeutic scan | - |
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