Relative contributions of insulin resistance and -cell dysfunction to the development of Type2 diabetes in Koreans
DC Field | Value | Language |
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dc.contributor.author | Kim, C. -H. | - |
dc.contributor.author | Kim, H. -K. | - |
dc.contributor.author | Kim, E. H. | - |
dc.contributor.author | Bae, S. J. | - |
dc.contributor.author | Park, J. -Y. | - |
dc.date.accessioned | 2021-08-12T00:47:02Z | - |
dc.date.available | 2021-08-12T00:47:02Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.issn | 1464-5491 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13422 | - |
dc.description.abstract | Aims Controversies still exist regarding the relative contributions of insulin resistance and -cell dysfunction to the pathogenesis of Type2 diabetes in different populations. We examined the associations of baseline insulin resistance and -cell function indices with the development of Type2 diabetes in Koreans. Methods We analysed the clinical and laboratory data of 17878 Korean adults (age 20-79years) who underwent routine medical examinations with a median interval of 3.5years (range 2.5-4.7years). Using the homeostasis model assessment, insulin resistance (HOMA-IR) and -cell function (HOMA-%B) indices at baseline were assessed. Results Those who developed diabetes (n=732, 4.1%) had significantly higher fasting serum insulin level (53.4 +/- 31.2 vs. 41.4 +/- 23.4pmol/l) and HOMA-IR (2.38 +/- 1.45 vs. 1.65 +/- 1.02) and lower HOMA-%B (74 +/- 47 vs. 85 +/- 48) at baseline (P<0.001 for all). Both high HOMA-IR and low HOMA-%B were independently associated with an increased odds ratio of incident Type2 diabetes. Among the participants who developed diabetes, 29% demonstrated predominant -cell dysfunction (HOMA-%B <25th percentile) and 51% had predominant insulin resistance (HOMA-IR >75th percentile). When we divided the participants according to the median BMI of the whole population (23.7kg/m(2)), 49% of participants in the low BMI group demonstrated predominant -cell dysfunction and 26% had predominant insulin resistance, whilst 21% in the high BMI group demonstrated mainly -cell dysfunction and 60% had mainly insulin resistance. Conclusions In individuals with low BMI, -cell dysfunction is the predominant defect, whereas insulin resistance is the predominant pathogenetic factor in individuals with high BMI in the development of Type2 diabetes in Koreans. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Relative contributions of insulin resistance and -cell dysfunction to the development of Type2 diabetes in Koreans | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/dme.12201 | - |
dc.identifier.scopusid | 2-s2.0-84882694110 | - |
dc.identifier.wosid | 000323195000011 | - |
dc.identifier.bibliographicCitation | Diabetic Medicine, v.30, no.9, pp 1075 - 1079 | - |
dc.citation.title | Diabetic Medicine | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1075 | - |
dc.citation.endPage | 1079 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | HOMEOSTASIS MODEL ASSESSMENT | - |
dc.subject.keywordPlus | GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
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