Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Mun, Seong Taek | - |
dc.date.accessioned | 2021-08-12T01:12:29Z | - |
dc.date.available | 2021-08-12T01:12:29Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13491 | - |
dc.description.abstract | In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of action, in a high-fat diet (HFD)-fed mice model. Mice were fed a HFD, or a HFD supplemented with 0.01% (w/w) CA or 0.02% (w/w) CA, for a period of 12 weeks, after which changes in body weight, blood lipid profiles, and fatty acid mechanism markers were evaluated. The 0.02% (w/w) CA diet resulted in a marked decline in steatosis grade, as well as in homeostasis model assessment of. insulin resistance (HOMA-IR) index values, intraperitoneal glucose tolerance test (IGTT) results, body weight gain, liver weight, and blood lipid levels (P < 0.05), The expression level of hepatic lipogenic genes, such as sterol regulating element binding protein-1c (SREBP-1c), liver-fatty acid binding protein (L-FABP), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase (FAS), was significantly lower in mice fed 0.01% (w/w) CA and 0.02% (w/w) CA diets than that in the HFD group; on the other hand, the expression level of beta-oxidation-related genes, such as peroxisome proliferator-activated receptor alpha (PPAR-alpha), carnitine palmitoyltransferase 1 (CPT-1), and acyl-CoA oxidase (ACO), was higher in mice fed a 0.02% (w/w) CA diet, than that in the HFD group (P < 0.05). In addition, the hepatic content of palmitic acid (C16:0), palmitoleic acid (C16:1), and oleic acid (C18:1) was significantly lower in mice fed the 0.02% (w/w) CA diet than that in the HFD group (P < 0.05). These results suggest that orally administered CA suppressed HFD-induced hepatic steatosis and fatty liver-related metabolic disorders through decrease of de novo lipogenesis and fatty acid elongation and increase of fatty acid beta-oxidation in mice. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국영양학회 | - |
dc.title | Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4162/nrp.2013.7.4.294 | - |
dc.identifier.scopusid | 2-s2.0-84882666003 | - |
dc.identifier.wosid | 000322687300008 | - |
dc.identifier.bibliographicCitation | Nutrition Research and Practice, v.7, no.4, pp 294 - 301 | - |
dc.citation.title | Nutrition Research and Practice | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 294 | - |
dc.citation.endPage | 301 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001791832 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DESATURASE | - |
dc.subject.keywordPlus | ROSEMARY | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Carnosic acid | - |
dc.subject.keywordAuthor | high-fat diet | - |
dc.subject.keywordAuthor | hepatic steatosis | - |
dc.subject.keywordAuthor | lipogenesis | - |
dc.subject.keywordAuthor | fatty acid oxidation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.