tert-Butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain
DC Field | Value | Language |
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dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Kim, Yong Hyun | - |
dc.contributor.author | Kwon, Hyun Jung | - |
dc.contributor.author | Rhee, Sang-Ki | - |
dc.contributor.author | Kim, Wan-Jong | - |
dc.contributor.author | Han, Man-Deuk | - |
dc.date.accessioned | 2021-08-12T01:13:20Z | - |
dc.date.available | 2021-08-12T01:13:20Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13554 | - |
dc.description.abstract | tert-Butylhydroquinone (tBHQ) is a commonly used antioxidant additive that is approved for human use by both the Food and Agriculture Organization and the World Health Organization (FAO/WHO). In this study, we examined the effect of tBHQ on body weight gain and found that food supplementation with 0.001 % (w/w) tBHQ inhibited 61.4 % (P < 0.01) of body weight gain in high-fat diet (HFD)-induced C57BL/6 mice, and the oral administration of tBHQ (1.5 mg/kg) reduced 47.5 % (P < 0.05) of body weight gain in normal diet fed db/db mice. The HFD increased lipid deposit in adipocytes, but these were reduced significantly by tBHQ treatment in C57BL/6 mice. tBHQ supplementation significantly lowered the plasma triglyceride and total cholesterol, with reduced size of accumulated fat mass. The rate limiting enzyme of beta-oxidation (ACOX1) was significantly over-expressed in the liver with tBHQ treatment. These results indicate that tBHQ suppresses body weight gain in mice, possibly at least related to the up-regulation of ACOX1 gene expression. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약학회 | - |
dc.title | tert-Butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12272-013-0109-3 | - |
dc.identifier.scopusid | 2-s2.0-84880042249 | - |
dc.identifier.wosid | 000321387500013 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, v.36, no.7, pp 897 - 904 | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 897 | - |
dc.citation.endPage | 904 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001910477 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | AGONIST | - |
dc.subject.keywordAuthor | tert-Butylhydroquinone | - |
dc.subject.keywordAuthor | ACOX1 | - |
dc.subject.keywordAuthor | Real-time RT-PCR | - |
dc.subject.keywordAuthor | Obesity | - |
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