Anti-solvent co-crystallization of carbamazepine and saccharin
DC Field | Value | Language |
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dc.contributor.author | Wang, In-Chun | - |
dc.contributor.author | Lee, Min-Jeong | - |
dc.contributor.author | Sim, Sang-Jun | - |
dc.contributor.author | Kim, Woo-Sik | - |
dc.contributor.author | Chun, Nan-Hee | - |
dc.contributor.author | Choi, Guang J. | - |
dc.date.accessioned | 2021-08-12T01:13:47Z | - |
dc.date.available | 2021-08-12T01:13:47Z | - |
dc.date.issued | 2013-06-25 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13583 | - |
dc.description.abstract | The co-crystal approach has been investigated extensively over the past decade as one of the most promising methods to enhance the dissolution properties of insoluble drug substances. Co-crystal powders are typically produced by mechanical grinding (neat or wet) or a solution method (evaporation or cooling). In this study, high-purity carbamazepine-saccharin (CBZ-SAC) co-crystals were manufactured by a novel method, anti-solvent addition. Among various solvents, methanol was found to perform well with water as the anti-solvent for the co-crystallization of CBZ and SAC. When water was added to the methanol solution of CBZ and SAC at room temperature under agitation, nucleation of CBZ-SAC co-crystals occurred within 2-3 min. Cocrystallization was complete after 30 min, giving a solid yield as high as 84.5% on a CBZ basis. The effects of initial concentrations, focusing on the SAC/ CBZ ratio, were examined to establish optimal conditions. The whole anti-solvent co-crystallization process was monitored at-line via ATR-FTIR analysis of regularly sampled solutions. The nucleation and crystal growth of CBZ-SAC co-crystals were detected by a significant increase in absorption in the range of 2400-2260 cm(-1), associated with the formation of hydrogen bonds between the carbonyl group in CBZ and the N-H of SAC. When CBZ hydrates were formed as impurities during anti-solvent co-crystallization, the hydrogen bonding between methanol and water was reduced greatly, primarily due to the incorporation of water molecules into the CBZ crystal lattice. In conclusion, an anti-solvent approach can be used to produce highly pure CBZ-SAC co-crystal powders with a high solid yield. (C) 2013 Elsevier B. V. All rights reserved. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Anti-solvent co-crystallization of carbamazepine and saccharin | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2013.04.012 | - |
dc.identifier.wosid | 000319444300035 | - |
dc.identifier.bibliographicCitation | International Journal of Pharmaceutics, v.450, no.1-2, pp 311 - 322 | - |
dc.citation.title | International Journal of Pharmaceutics | - |
dc.citation.volume | 450 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 322 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PHARMACEUTICAL COCRYSTALS | - |
dc.subject.keywordPlus | CO-CRYSTAL | - |
dc.subject.keywordPlus | SOLUBILITY ADVANTAGE | - |
dc.subject.keywordPlus | ACID COCRYSTAL | - |
dc.subject.keywordPlus | DISSOLUTION | - |
dc.subject.keywordPlus | EVAPORATION | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | FORM | - |
dc.subject.keywordAuthor | Co-crystal | - |
dc.subject.keywordAuthor | Carbamazepine Saccharin Anti | - |
dc.subject.keywordAuthor | solvent crystallization | - |
dc.subject.keywordAuthor | ATR | - |
dc.subject.keywordAuthor | FTIR | - |
dc.subject.keywordAuthor | Hydrogen bonding | - |
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