Japanese bog orchid (Eupatorium japonicum) extract suppresses expression of inducible nitric oxide synthase and cyclooxygenase-2 induced by toll-like receptor agonists
DC Field | Value | Language |
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dc.contributor.author | Gu, Gyo-Jeong | - |
dc.contributor.author | Eom, Sang-Hoon | - |
dc.contributor.author | Shin, Hwa-Jeong | - |
dc.contributor.author | Paek, Ji Hun | - |
dc.contributor.author | Kim, Songmun | - |
dc.contributor.author | Lim, Soon Sung | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-12T01:14:20Z | - |
dc.date.available | 2021-08-12T01:14:20Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.issn | 2092-6456 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13644 | - |
dc.description.abstract | Toll-like receptors (TLR) play an important role in the recognition of many pathogen-associated molecular patterns and the induction of innate immunity. Dysregulated activation of TLR signaling pathways is associated with certain inflammatory diseases. Japanese bog orchid (Eupatorium japonicum), which belongs to a family of Asteraceae plants, is consumed as a tea. The present study investigated the effect of the ethanol extracts of flowers of Japanese bog orchid (EJE) on nuclear factor (NF)-kappa B activation and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by TLR agonists in murine macrophages. EJE suppressed NF-kappa B activation and iNOS and COX-2 expression induced by lipopolysaccharide (TLR4 agonist), polyriboinosinic polyribocytidylic acid (TLR3), and macrophage-activating 2 kDa lipopeptide (TLR2 and TLR6). These results suggest that EJE can regulate TLR signaling pathways and indicated its potential as a potent anti-inflammatory drug. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국식품과학회 | - |
dc.title | Japanese bog orchid (Eupatorium japonicum) extract suppresses expression of inducible nitric oxide synthase and cyclooxygenase-2 induced by toll-like receptor agonists | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s10068-013-0149-y | - |
dc.identifier.scopusid | 2-s2.0-84879640923 | - |
dc.identifier.wosid | 000321071000030 | - |
dc.identifier.bibliographicCitation | Food Science and Biotechnology, v.22, no.3, pp 811 - 815 | - |
dc.citation.title | Food Science and Biotechnology | - |
dc.citation.volume | 22 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 811 | - |
dc.citation.endPage | 815 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001784915 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PATHOGEN RECOGNITION | - |
dc.subject.keywordPlus | INFLAMMATORY CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordPlus | RIP1 | - |
dc.subject.keywordPlus | TBK1 | - |
dc.subject.keywordAuthor | Eupatorium japonicum | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | inducible nitric oxide synthase | - |
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