Evaluation of structural and functional changes in non-pathologic myopic fundus using multifocal electroretinogram and optical coherence tomography

Abstract

To evaluate structural and functional changes in non-pathologic myopic fundus using multifocal electroretinogram (mfERG) and spectral domain-optical coherence tomography (SD-OCT). A total of 90 myopic subjects underwent mfERG and SD-OCT. The subjects were divided into four groups according to spherical equivalent refractive error: Group 1 (-0.50 to -2.75 D), Group 2 (-3.00 to -5.75 D), Group 3 (-6.00 to -9.75 D), and Group 4 (-10.0 to -15.0 D). Total retinal thickness, photoreceptor retinal thickness (PR), outer nuclear retinal thickness and mid-inner retinal thickness (MIR) were measured using SD-OCT in foveola and two perifoveal retinal regions 2.0 mm nasal and temporal from the foveola. The amplitude and implicit time of N1 and P1 mfERG responses were analyzed using six-concentric-ring grouping. Correlations between each retinal thickness, amplitude, and implicit time among the four myopic groups were analyzed. PR thickness in the foveola and MIR thickness in the perifoveal retina were significantly reduced with increasing myopic refractive errors (p = 0.001, respectively). Significant correlations appeared between N1 amplitude, P1 amplitude, P1 implicit time, and refractive errors (p = 0.001, respectively). Significant correlations appeared between MIR thickness and N1, P1 amplitude (p = 0.001, respectively) as well as N1, P1 implicit time (p = 0.02 and 0.03, respectively) in the perifoveal retina corresponding to ring 4. The correlation between structural and functional changes in myopia should be considered when interpreting retinal structure and function using SD-OCT and mfERG, especially in high myopia.