Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Nyun | - |
dc.contributor.author | Park, Man Sik | - |
dc.contributor.author | Lim, Kang Il | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Kang, Hyun Joo | - |
dc.contributor.author | Song, Wook | - |
dc.contributor.author | Choi, Hyuk | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.date.accessioned | 2021-08-12T01:18:22Z | - |
dc.date.available | 2021-08-12T01:18:22Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.issn | 1365-2265 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13816 | - |
dc.description.abstract | Objective It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) 100cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results The prevalence of SO was 17 center dot 8% in men and 24 center dot 9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1365-2265.2012.04433.x | - |
dc.identifier.scopusid | 2-s2.0-84875145642 | - |
dc.identifier.wosid | 000316229400008 | - |
dc.identifier.bibliographicCitation | Clinical Endocrinology, v.78, no.4, pp 525 - 532 | - |
dc.citation.title | Clinical Endocrinology | - |
dc.citation.volume | 78 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 525 | - |
dc.citation.endPage | 532 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | MUSCLE MASS SARCOPENIA | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | OLDER PERSONS | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | CARDIOVASCULAR RISK | - |
dc.subject.keywordPlus | BODY-COMPOSITION | - |
dc.subject.keywordPlus | LEAN MASS | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | . | - |
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