Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase
- Authors
- Park, Hye-Jeong; Youn, Hyung-Sun
- Issue Date
- Mar-2013
- Publisher
- SAGE Publications
- Keywords
- Mercury; inflammation; nuclear factor-kappa B; cyclooxygenase-2; inducible nitric oxide synthase
- Citation
- Toxicology and Industrial Health, v.29, no.2, pp 169 - 174
- Pages
- 6
- Journal Title
- Toxicology and Industrial Health
- Volume
- 29
- Number
- 2
- Start Page
- 169
- End Page
- 174
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13859
- DOI
- 10.1177/0748233711427048
- ISSN
- 0748-2337
1477-0393
- Abstract
- Nuclear factor-kappa B (NF-kappa B) is a transcription factor that mediates the inducible expression of a variety of genes involved in immune and inflammatory responses. NF-kappa B activation induces numerous proinflammatory gene products including cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). The divalent heavy metal mercury has been used for thousands of years. Although mercury is clearly toxic to most mammalian organ systems, especially the immune system, exposure has still increased in some areas of the world. However, the underlying toxic mechanism is not clearly identified. Here, we report biochemical evidence that mercury alone induces NF-kappa B activation, resulting in the induced expression of COX-2 and 'NOS. The results suggest that mercury can induce inflammatory diseases by lowering host defense.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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