Mast Cell Stabilizing Effect of (-)-Elema-1,3,11(13)-trien-12-ol and Thujopsene from Thujopsis dolabrata Is Mediated by Down-Regulation of Interleukin-4 Secretion in Antigen-Induced RBL-2H3 Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Lee, Taehun | - |
dc.contributor.author | Oh, Ikhoon | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Kim, Kyeong Ho | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Mar, Woongchon | - |
dc.date.accessioned | 2021-08-12T01:24:36Z | - |
dc.date.available | 2021-08-12T01:24:36Z | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.issn | 1347-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13895 | - |
dc.description.abstract | Several isolated compounds from the wood part of Thujopsis dolabrata were evaluated for their inhibitory effects against antigen-induced mast cell degranulation and interleukin-4 (IL-4) secretion, as well as IL-4 mRNA and protein expression in immunoglobulin E (IgE)-sensitized RBL-2H3 cells. Among the five isolated compounds, (-)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) exhibited the potent inhibitory activity against mast cell degranulation measured by beta-hexosaminidase release with IC50 values of 27.4 mu m and 25.1 mu m, respectively. These compounds also inhibited the release of IL-4 (IC50 values of 7.0, 6.7 mu m, respectively), IL-4 mRNA expression (IC50 values of 16.5, 7.2 mu m, respectively) and IL-4 protein expression (IC50 values of 17.0, 9.6 mu m, respectively) in antigen-induced IgE-sensitized RBL-2H3 cells. These results suggested that (-)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) effectively inhibits mast cell degranulation as well as IL-4 production, suggesting that these compounds from Thujopsis dolabrata can be used as candidates for IgE-mediated allergic disorders. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pharmaceutical Society of Japan | - |
dc.title | Mast Cell Stabilizing Effect of (-)-Elema-1,3,11(13)-trien-12-ol and Thujopsene from Thujopsis dolabrata Is Mediated by Down-Regulation of Interleukin-4 Secretion in Antigen-Induced RBL-2H3 Cells | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1248/bpb.b12-00375 | - |
dc.identifier.wosid | 000315472500002 | - |
dc.identifier.bibliographicCitation | Biological and Pharmaceutical Bulletin, v.36, no.3, pp 339 - 345 | - |
dc.citation.title | Biological and Pharmaceutical Bulletin | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 339 | - |
dc.citation.endPage | 345 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | BETA-HEXOSAMINIDASE | - |
dc.subject.keywordPlus | SAUSSUREA-LAPPA | - |
dc.subject.keywordPlus | HINOKITIOL | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | IL-4 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SESQUITERPENES | - |
dc.subject.keywordAuthor | Thujopsis dolabrata | - |
dc.subject.keywordAuthor | RBL-2H3 cell | - |
dc.subject.keywordAuthor | mast cell degranulation | - |
dc.subject.keywordAuthor | interleukin-4 | - |
dc.subject.keywordAuthor | beta-hexosaminidase | - |
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