Altered expression of adrenocorticotropic hormone in the epileptic gerbil hippocampus following spontaneous seizure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Yun-Jung | - |
dc.contributor.author | Kim, Heung-No | - |
dc.contributor.author | Jeong, Ji-Heon | - |
dc.contributor.author | Park, Dae-Kyoon | - |
dc.contributor.author | Park, Kyung-Ho | - |
dc.contributor.author | Ko, Jeong-Sik | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.date.accessioned | 2021-08-12T01:24:43Z | - |
dc.date.available | 2021-08-12T01:24:43Z | - |
dc.date.issued | 2013-02-28 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13899 | - |
dc.description.abstract | We investigated the temporal alterations of adrenocorticotropic hormone (ACTH) immunoreactivity in the hippocampus after seizure onset. Expression of ACTH was observed within interneurons in the pre-seizure group of seizure sensitive gerbils, whereas its immunoreactivities were rarely detected in seizure resistant gerbil. Three hr after the seizure, ACTH immunoreactivity was significantly increased in interneurons within all hippocampal regions. On the basis of their localization and morphology through immunofluorescence staining, these cells were identified as GABA(A) alpha 1-containing interneurons. At the 12 hr postictal period, ACTH expression in these regions was down-regulated, in a similar manner to the pre-seizure group of gerbils. These findings support the increase in ACTH synthesis that contributes to a reduction of corticotrophin-releasing factor via the negative feedback system which in turn provides an opportunity to enhance the excitability of GABAergic interneurons. Therefore, ACTH may play an important role in the reduction of excitotoxicity in all hippocampal regions. [BMB Reports 2013; 46(2): 80-85] | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Altered expression of adrenocorticotropic hormone in the epileptic gerbil hippocampus following spontaneous seizure | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2013.46.2.149 | - |
dc.identifier.scopusid | 2-s2.0-84874682060 | - |
dc.identifier.wosid | 000318073100003 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.46, no.2, pp 80 - 85 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 46 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 85 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001744065 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CORTICOTROPIN-RELEASING-FACTOR | - |
dc.subject.keywordPlus | TEMPORAL-LOBE EPILEPSY | - |
dc.subject.keywordPlus | INFANTILE SPASMS | - |
dc.subject.keywordPlus | RECEPTOR IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | MONGOLIAN GERBIL | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | PRECIPITANTS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | PITUITARY | - |
dc.subject.keywordAuthor | Adrenocorticotropic hormone | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Gerbil | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.