Leukocyte chemotactic cytokine and leukocyte subset responses during ultra-marathon running
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Young Oh | - |
dc.contributor.author | Lee, Jeong Beom | - |
dc.date.accessioned | 2021-08-12T01:25:16Z | - |
dc.date.available | 2021-08-12T01:25:16Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.issn | 1096-0023 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13947 | - |
dc.description.abstract | Purpose: The aim of this study was to assess leukocyte chemotactic cytokine and leukocyte subset responses during ultra-marathon running. Leukocyte chemokines such as interleukin (IL)-8,interferon gamma-induced protein-10 (IF-10), regulated upon activation, normal T-cell expressed and secreted (RANTES), and eotaxin are involved in leukocyte recruitment. Methods: Among 60 male amateur endurance runner volunteers, 18 finished the course (a 308 km continuous race from Kanghwado to Kangneung, South Korea). Their average age, height, and body mass were 52.8 +/- 5.0 years, 167.6 +/- 5.2 cm, and 64.5 +/- 1.2 kg, respectively. Blood samples were collected at 0, 100, 200, and 308 km during the race for analysis of white blood cells and serum concentrations of IL-8, IP-10, RANTES, eotaxin, IL-6, creatine kinase (CM), and C-reactive protein (CRP). Results: Muscle and liver damage indicators (IL-6, CK, and CRP) were maximally elevated as a result of marathon running. Total leukocytes, neutrophils, and monocytes increased significantly during the event (leukocytosis, neutrophilia, and monocytosis, respectively). However, lymphocytes and eosinophils decreased significantly during the event (lymphopenia and eosinopenia, respectively). Serum levels of the neutrophil chemokine IL-8 increased maximally at 100 km and were maintained. Monocyte-lymphocyte chemokine IP-10 concentration decreased during the latter part of the race. The eosinophil chemokine eotaxin decreased gradually during the race, and no difference was observed in eosinophil chemokine RANTES levels. Conclusion: These observations indicate that prolonged endurance ultra-marathon running was associated with significant systemic inflammation and perturbation in leukocyte subsets. Leukocyte chemotactic cytokines such as IL-8, IP-10, eotaxin showed similar patterns of responses in related leukocyte subsets, but RANTES did not. (c) 2012 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | Leukocyte chemotactic cytokine and leukocyte subset responses during ultra-marathon running | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.cyto.2012.11.019 | - |
dc.identifier.scopusid | 2-s2.0-84873110025 | - |
dc.identifier.wosid | 000314742800008 | - |
dc.identifier.bibliographicCitation | Cytokine, v.61, no.2, pp 364 - 369 | - |
dc.citation.title | Cytokine | - |
dc.citation.volume | 61 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 364 | - |
dc.citation.endPage | 369 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | RESPIRATORY-TRACT INFECTION | - |
dc.subject.keywordPlus | HUMAN SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | STRENUOUS EXERCISE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CHEMOATTRACTANT | - |
dc.subject.keywordPlus | NASOPHARYNGEAL | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | SECRETIONS | - |
dc.subject.keywordAuthor | Ultra-marathon | - |
dc.subject.keywordAuthor | Serum | - |
dc.subject.keywordAuthor | Chemokine | - |
dc.subject.keywordAuthor | Leukocyte | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.