Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists
DC Field | Value | Language |
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dc.contributor.author | Shin, Hwa-Jeong | - |
dc.contributor.author | Shon, Dong-Hwa | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-12T01:26:29Z | - |
dc.date.available | 2021-08-12T01:26:29Z | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14038 | - |
dc.description.abstract | Toll-like receptors (TLRs) play an important role by recognizing many pathogen-associated molecular patterns and inducing innate immunity. Dysregulated activation of TLR signaling pathways induces the activation of various transcription factors such as nuclear factor-kappa B, leading to the induction of pro-inflammatory gene products such as inducible nitric oxide synthase (iNOS). The present study investigated the effect of isobavachalcone (IBC), a natural chalcone component of Angelica keiskei, on inflammation by modulating iNOS expression induced by TLR agonists in murine macrophages. IBC suppressed iNOS expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide. These results indicate the potential of IBC as a potent anti-inflammatory drug. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.intimp.2012.11.005 | - |
dc.identifier.scopusid | 2-s2.0-84872292708 | - |
dc.identifier.wosid | 000315075400006 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, v.15, no.1, pp 38 - 41 | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 41 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANGELICA-KEISKEI | - |
dc.subject.keywordPlus | ANTIMETASTATIC ACTIVITIES | - |
dc.subject.keywordPlus | INFLAMMATORY CELLS | - |
dc.subject.keywordPlus | CHALCONES | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | TBK1 | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Isobavachalcone | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Toll-like receptors | - |
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