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Isoliquiritigenin Inhibits Ovalbumin-induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase ExpressionIsoliquiritigenin Inhibits Ovalbumin-induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
- Other Titles
- Isoliquiritigenin Inhibits Ovalbumin-induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
- Issue Date
- 2013
- Publisher
- 대한의생명과학회
- Keywords
- Egg allergy; Isoliquiritigenin; Inducible nitric oxide synthase; Cyclooxygenase-2; Ovalbumin
- Citation
- 대한의생명과학회지, v.19, no.3, pp.270 - 274
- Journal Title
- 대한의생명과학회지
- Volume
- 19
- Number
- 3
- Start Page
- 270
- End Page
- 274
- Abstract
- Egg allergy has been raised as the most prevalent food hypersensitivity in children. Ovalbumin (OVA), which is one of the major egg allergens, is the major protein in egg white. Isoliquiritigenin (ILG) is an active component present in licorice and has been used to treat many chronic diseases for many years. In this study, we present biochemical evidence that ILG inhibits OVA-induced nuclear factor-κB (NF-κB) activation. ILG also inhibits OVA-induced cyclooxygenase-2(COX-2) and inducible nitric oxide synthase (iNOS) expression. These data suggest that ILG has anti-allergy effects.
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Related Researcher
- youn, hyung sun
- College of Medical Sciences (Department of Biomedical Laboratory Science)