피하층 열상 쥐모델에서 Polydeoxyribonucleotide (PDRN)가 봉합치료에 미치는 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재윤 | - |
dc.contributor.author | 김호중 | - |
dc.contributor.author | 이종빈 | - |
dc.contributor.author | 성수동 | - |
dc.contributor.author | 조영순 | - |
dc.date.accessioned | 2021-08-12T01:44:37Z | - |
dc.date.available | 2021-08-12T01:44:37Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1226-4334 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14248 | - |
dc.description.abstract | Purpose: To evaluate the effectiveness of polydeoxyribonucleotide (PDRN) material on murine subcutaneous laceration wounds. Methods: Subcutaneous laceration wounds were made on the back of mice. The mice were divided into two groups according to method of PDRN applied: Group I (control,general dressing, and management) and Group II (PDRN injection). We evaluated gross findings and histological findings for the groups. Results: A total of 18 mice (9 in the Suture group and 9with Suture+PDRN) were enrolled. In the mean results of gross finding (5-point Likert scale), the mean gross findings for wounds in the PDRN group were significantly higher than the suture groups on post-operative day 4 and 7 (for day 4, Suture: 2, Suture+PDRN: 3.2; for day 7, Suture: 2.7,Suture+PDRN: 4.2; p<0.05). In the histological analysis of wounds in the Suture+PDRN group after 10 days, reepithelization and granulation tissue formation were better than the Suture group. In terms of wound-healing grade, reepithelization and inflammation were not different; however,in the Suture+PDRN group, more granulation tissue formation was noted compared to the Suture group (p<0.05). In addition, the expression of VEGF in the Suture+PDRN group significantly increased compared to the Suture group (Suture: 11170±2475, Suture + PDRN: 27243±6621,p<0.05). Conclusion: The Suture+PDRN group can be used for the early treatment and histological healing of subcutaneous laceration wounds. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한응급의학회 | - |
dc.title | 피하층 열상 쥐모델에서 Polydeoxyribonucleotide (PDRN)가 봉합치료에 미치는 효과 | - |
dc.title.alternative | Effectiveness of Polydeoxyribonucleotide (PDRN) Material on Murine Subcutaneous Laceration Wounds | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김호중 | - |
dc.contributor.affiliatedAuthor | 조영순 | - |
dc.identifier.bibliographicCitation | 대한응급의학회지, v.24, no.4, pp.453 - 458 | - |
dc.relation.isPartOf | 대한응급의학회지 | - |
dc.citation.title | 대한응급의학회지 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 458 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001800813 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | PDRN | - |
dc.subject.keywordAuthor | Polydeoxyribonucleotide | - |
dc.subject.keywordAuthor | Subcutaneous | - |
dc.subject.keywordAuthor | Laceration | - |
dc.subject.keywordAuthor | Wound | - |
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