Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seul-Ki | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.date.accessioned | 2021-08-12T02:25:14Z | - |
dc.date.available | 2021-08-12T02:25:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0716-9760 | - |
dc.identifier.issn | 0717-6287 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14568 | - |
dc.description.abstract | Electrolyzed-reduced water (ERW) scavenges reactive oxygen species and is a powerful anti-oxidant. A positive correlation between oxidative stress and aging has been proved in many model organisms. In Caenorhabditis elegans, many long-lived mutants showed reduced fertility as a trade off against longevity phenotype. We aimed to study the effect of ERW on oxidative stress, fertility and lifespan of C. elegans. We also investigated the genetic pathway involved in the effect of ERW on resistance to oxidative stress and lifespan. We compared lifespan and fertility of worms in media prepared with distilled water and ERW. ERW significantly extended lifespan and increased the number of progeny produced. Then the effect of ERW on resistance to oxidative stress and lifespan of long-lived mutants was determined. ERW increased resistance to oxidative stress and lifespan of eat-2, a genetic model of dietary restriction, but had no effect on those of age-1, which is involved in insulin/insulin-like growth factor (IGF)-1-like signal. In addition, knockdown of daf-16, the downstream mediator of insulin/IGF-1-like signal, completely prevented the effect of ERW on lifespan. These findings suggest that ERW can extend lifespan without accompanying reduced fertility and modulate resistance to oxidative stress and lifespan via insulin/IGF-1-like signal in C. elegans. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Sociedad de Biologia de Chile | - |
dc.title | Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans | - |
dc.type | Article | - |
dc.publisher.location | 칠레 | - |
dc.identifier.doi | 10.4067/S0716-97602013000200005 | - |
dc.identifier.scopusid | 2-s2.0-84882774195 | - |
dc.identifier.wosid | 000322100800005 | - |
dc.identifier.bibliographicCitation | Biological Research, v.46, no.2, pp 147 - 152 | - |
dc.citation.title | Biological Research | - |
dc.citation.volume | 46 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 152 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | CALORIC RESTRICTION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | EXTENSION | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | Electrolyzed-reduced water | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | daf-16 | - |
dc.subject.keywordAuthor | fertility | - |
dc.subject.keywordAuthor | lifespan | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.