Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B
- Authors
- Kim, Suk Bae; Song, Il Han; Kim, Young Min; Noh, Ran; Kang, Ha Yan; Lee, Hyang Ie; Yang, Hyeon Yoong; Kim, An Na; Chae, Hee Bok; Lee, Sae Hwan; Kim, Hong Soo; Lee, Tae Hee; Kang, Young Woo; Lee, Eaum Seok; Kim, Seok Hyun; Lee, Byung Seok; Lee, Heon Young
- Issue Date
- 21-Dec-2012
- Publisher
- Baishideng Publishing Group
- Keywords
- Chronic hepatitis B; Hepatitis B virus; Clevudine; Entecavir; Treatment outcomes
- Citation
- World Journal of Gastroenterology, v.18, no.47, pp 6943 - 6950
- Pages
- 8
- Journal Title
- World Journal of Gastroenterology
- Volume
- 18
- Number
- 47
- Start Page
- 6943
- End Page
- 6950
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14590
- DOI
- 10.3748/wjg.v18.i47.6943
- ISSN
- 1007-9327
2219-2840
- Abstract
- AIM: To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B (CHB). METHODS: We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/d. The biochemical response, as assessed by serum alanine aminotransferase (ALT) activity, virologic response, as assessed by serum hepatitis B virus DNA (HBV DNA) titer, serologic response, as assessed by hepatitis B e antigen (HBeAg) status, and virologic breakthrough with genotypic mutations were assessed. RESULTS: Two-hundred and fifty-four patients [clevudine (n = 118) vs entecavir (n = 136)] were enrolled. In clevudine-treated patients, the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96 (80.9% and 91.2% in the entecavir group, respectively), the mean titer changes in serum HBV DNA were -6.03 and -6.55 log(10) copies/mL (-6.35 and -6.86 log(10) copies/mL, respectively, in the entecavir group), and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1% (74.4% and 83.8%, respectively, in the entecavir group). These results were similar to those of entecavir-treated patients. The cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine, which was similar to patients treated with entecavir (22.8% and 27.7%, respectively). The virologic breakthrough in the clevudine group occurred in 9 (7.6%) patients at weeks 48 and 15 (12.7%) patients at week 96, which primarily corresponded to genotypic mutations of rtM204I and/or rtL180M. There was no virologic breakthrough in the entecavir group. CONCLUSION: In antiviral-naive CHB patients, long-term treatment outcomes of clevudine were not inferior to those of entecavir, except for virologic breakthrough. (C) 2012 Baishideng. All rights reserved.
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