Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Sik | - |
dc.contributor.author | Kim, Eun-Ae | - |
dc.contributor.author | Park, Kyu-Gun | - |
dc.contributor.author | Lee, Sung-Jun | - |
dc.contributor.author | Kim, Mi-Sun | - |
dc.contributor.author | Sohn, Ho-Yong | - |
dc.contributor.author | Lee, Tae-Jin | - |
dc.date.accessioned | 2021-08-12T02:27:06Z | - |
dc.date.available | 2021-08-12T02:27:06Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14727 | - |
dc.description.abstract | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received attention as a potential anticancer drug, because it induces apoptosis in a wide variety of cancer cells but not in most normal human cell types. Here, we showed that co-treatment with subtoxic doses of dioscin and TRAIL-induced apoptosis in Caki human renal cancer cells. Treatment of Caki cells with dioscin downregulated c-FLIPL and Bcl-2 proteins in a dose-dependent manner. Dioscin-induced decrease in c-FLIPL protein levels may be caused by the increased protein instability. We also found that dioscin induced downregulation of Bcl-2 at the transcriptional level. Pretreatment with NAC slightly inhibited the expression levels of c-FLIPL downregulated by the treatment of dioscin, suggesting that dioscin is partially dependent on the generation of ROS for downregulation of c-FLIPL. Taken together, the present study demonstrates that dioscin enhances TRAIL-induced apoptosis in human renal cancer cells by downregulation of c-FLIPL and Bcl-2. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2 | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/or.2012.1962 | - |
dc.identifier.scopusid | 2-s2.0-84866445045 | - |
dc.identifier.wosid | 000310657900054 | - |
dc.identifier.bibliographicCitation | Oncology Reports, v.28, no.5, pp 1910 - 1916 | - |
dc.citation.title | Oncology Reports | - |
dc.citation.volume | 28 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1910 | - |
dc.citation.endPage | 1916 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | dioscin | - |
dc.subject.keywordAuthor | tumor necrosis factor-related apoptosis-inducing ligand | - |
dc.subject.keywordAuthor | c-FLIP | - |
dc.subject.keywordAuthor | Bcl-2 | - |
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