Single dose toxicity studies of sulfated water soluble beta-D-glucan in Sprague-Dawley rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong Hyun | - |
dc.contributor.author | Paek, Jong Yoon | - |
dc.contributor.author | Shin, Hyun-Woung | - |
dc.contributor.author | Han, Man-Deuk | - |
dc.date.accessioned | 2021-08-12T02:27:08Z | - |
dc.date.available | 2021-08-12T02:27:08Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0254-8704 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14729 | - |
dc.description.abstract | The fungal beta-D-glucan is a biological response modifier (BRM), but a major obstacle to the clinical utilization of these BRMs is their relative insolubility in aqueous media. We made soluble sulfated-beta-glucan (SGL) from insoluble beta-glucan (IGL) by sulfation method. In single dose toxicity study of SGL for 7 days, no negative effects on body weight or food consumption of rats were evident below a dose rate of 2,000 mg kg(-1) SGL. No clinical pathology, functional/behavioral, or gross observations indicating toxicity were detected. In hematology and biochemistry, statistically significant increases of WBC and neutrophils (P<0.01) in male and increase of MCV (P<0.05) in females was observed. However, since the changes were not dose responsive, the effects were considered to be of no toxicological significance. These results suggest that chemically modified sulfated-beta-Dglucan was less toxic than the insoluble b-glucan and not considered acutely toxic following peritoneal exposure to 2,000mg kg(-1) day(-1) in Sprague-Dawley rats. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academy of Environmental Biology | - |
dc.title | Single dose toxicity studies of sulfated water soluble beta-D-glucan in Sprague-Dawley rats | - |
dc.type | Article | - |
dc.publisher.location | 인도 | - |
dc.identifier.scopusid | 2-s2.0-84870047843 | - |
dc.identifier.wosid | 000310667300022 | - |
dc.identifier.bibliographicCitation | Journal of Environmental Biology, v.33, no.6, pp 1107 - 1114 | - |
dc.citation.title | Journal of Environmental Biology | - |
dc.citation.volume | 33 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1107 | - |
dc.citation.endPage | 1114 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | GANODERMA-LUCIDUM | - |
dc.subject.keywordPlus | POLYSACCHARIDES | - |
dc.subject.keywordPlus | SOLUBILIZATION | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordAuthor | Sulfated-beta-D-glucan | - |
dc.subject.keywordAuthor | Ganoderma lucidum | - |
dc.subject.keywordAuthor | Single dose toxicity | - |
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