RETRACTED: Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury (Retracted article. See vol. 45, e24, 2013)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Hoon Jae | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Kim, Mi Jin | - |
dc.contributor.author | Woo, Su Jung | - |
dc.contributor.author | Kim, Hye Ri | - |
dc.contributor.author | Kim, So Mi | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Hwang, Hyun Sook | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Won, Moo Ho | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-12T02:27:38Z | - |
dc.date.available | 2021-08-12T02:27:38Z | - |
dc.date.issued | 2012-10-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14755 | - |
dc.description.abstract | Reactive oxygen species (ROS) contribute to the development of a number of neuronal diseases including ischemia. DJ-1, also known to PARK7, plays an important role in transcriptional regulation, acting as molecular chaperone and antioxidant. In the present study, we investigated whether DJ-1 protein shows a protective effect against oxidative stress-induced neuronal cell death in vitro and in ischemic animal models in vivo. To explore DJ-1 protein's potential role in protecting against ischemic cell death, we constructed cell permeable Tat-DJ-1 fusion proteins. Tat-DJ-1 protein efficiently transduced into neuronal cells in a dose-and time-dependent manner. Transduced Tat-DJ-1 protein increased cell survival against hydrogen peroxide (H2O2) toxicity and also reduced intracellular ROS. In addition, Tat-DJ-1 protein inhibited DNA fragmentation induced by H2O2. Furthermore, in animal models, immunohistochemical analysis revealed that Tat-DJ-1 protein prevented neuronal cell death induced by transient forebrain ischemia in the CA1 region of the hippocampus. These results demonstrate that transduced Tat-DJ-1 protein protects against cell death in vitro and in vivo, suggesting that the transduction of Tat-DJ-1 may be useful as a therapeutic agent for ischemic injuries related to oxidative stress. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | RETRACTED: Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury (Retracted article. See vol. 45, e24, 2013) | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3858/emm.2012.44.10.067 | - |
dc.identifier.scopusid | 2-s2.0-84868105314 | - |
dc.identifier.wosid | 000310770700003 | - |
dc.identifier.bibliographicCitation | Experimental & Molecular Medicine, v.44, no.10, pp 586 - 593 | - |
dc.citation.title | Experimental & Molecular Medicine | - |
dc.citation.volume | 44 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 586 | - |
dc.citation.endPage | 593 | - |
dc.type.docType | Article; Retracted Publication | - |
dc.identifier.kciid | ART001705689 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | DISEASE GENE DJ-1 | - |
dc.subject.keywordPlus | EFFICIENTLY PROTECTS | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | NEURONAL APOPTOSIS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | TECHNOLOGY | - |
dc.subject.keywordAuthor | brain ischemia | - |
dc.subject.keywordAuthor | CA1 region | - |
dc.subject.keywordAuthor | hippocampal | - |
dc.subject.keywordAuthor | cell survival | - |
dc.subject.keywordAuthor | neurons | - |
dc.subject.keywordAuthor | PARK7 protein | - |
dc.subject.keywordAuthor | human | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | toxicity | - |
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