Early human papillomavirus testing predicts residual/recurrent disease after LEEP
DC Field | Value | Language |
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dc.contributor.author | Ryu, Aeli | - |
dc.contributor.author | Nam, Kyehyun | - |
dc.contributor.author | Kwak, Jeongja | - |
dc.contributor.author | Kim, Jeongsig | - |
dc.contributor.author | Jeon, Seob | - |
dc.date.accessioned | 2021-08-12T02:44:46Z | - |
dc.date.available | 2021-08-12T02:44:46Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.issn | 2005-0399 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14800 | - |
dc.description.abstract | Objective: The purpose of this study was to determine the predictive factors for residual/recurrent disease and to analyze the timing for Pap smears and human papillomavirus (HPV) testing during follow-up after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2 or worse. Methods: We retrospectively analyzed 183 patients (mean age, 39.3 years) with CIN 2/3 who were treated with LEEP. Post-LEEP follow-up was performed by Pap smear and HPV hybrid capture2 (HC2) testing. The definition of persistent/recurrent disease was biopsy-proven CIN 2 or worse. Results: Among 183 patients, punch biopsies were CIN 2 in 31 (16.9%) and CIN 3 in 152(83.1%). HPV HC2 tests before LEEP were positive in 170(95.5%) of 178 patients. During follow-up, 12 patients (6.6%) had residual/recurrent CIN 2+. LEEP margin status was a significant predictive factor for persistent/recurrent disease. Other factors such as age, HPV HC2 viral load (>= 100 relative light units), and HPV typing (type 16/18 vs. other types) did not predict recurrence. Early HPV HC2 testing at 3 months after LEEP detected all cases of residual/recurrent disease. The sensitivity and negative predictive value of the HPV HC2 test for residual/recurrent disease were both 100% at 3 and 6 months. Conclusion: Margin involvement in conization specimens was a significant factor predicting-residual/recurrent disease after LEEP. HPV test results at 3 and 6 months after treatment were comparable. Early 3-month follow-up testing after LEEP can offer timely information about residual/recurrent disease and alleviate patient anxiety early about treatment failure. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한부인종양학회 | - |
dc.title | Early human papillomavirus testing predicts residual/recurrent disease after LEEP | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3802/jgo.2012.23.4.217 | - |
dc.identifier.scopusid | 2-s2.0-84867182369 | - |
dc.identifier.wosid | 000309041200003 | - |
dc.identifier.bibliographicCitation | Journal of Gynecologic Oncology, v.23, no.4, pp 217 - 225 | - |
dc.citation.title | Journal of Gynecologic Oncology | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 225 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001704150 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | CERVICAL INTRAEPITHELIAL NEOPLASIA | - |
dc.subject.keywordPlus | LOOP ELECTROSURGICAL EXCISION | - |
dc.subject.keywordPlus | TRANSFORMATION ZONE LLETZ | - |
dc.subject.keywordPlus | LONG-TERM RISK | - |
dc.subject.keywordPlus | INCOMPLETE EXCISION | - |
dc.subject.keywordPlus | TREATMENT FAILURE | - |
dc.subject.keywordPlus | NEGATIVE MARGINS | - |
dc.subject.keywordPlus | HPV PERSISTENCE | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | INVASIVE CANCER | - |
dc.subject.keywordAuthor | Cervical intraepithelial neoplasia | - |
dc.subject.keywordAuthor | Follow-up | - |
dc.subject.keywordAuthor | Human papillomavirus | - |
dc.subject.keywordAuthor | Loop electrosurgical excision procedure | - |
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