Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung-Jin | - |
dc.contributor.author | Ahn, Hyunjin | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Kim, Kyeong Ho | - |
dc.contributor.author | Mar, Woongchon | - |
dc.date.accessioned | 2021-08-12T02:45:32Z | - |
dc.date.available | 2021-08-12T02:45:32Z | - |
dc.date.issued | 2012-09-30 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14832 | - |
dc.description.abstract | The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mu M H2O2, as assessed by 4',6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국응용약물학회 | - |
dc.title | Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4062/biomolther.2012.20.5.487 | - |
dc.identifier.scopusid | 2-s2.0-84867249878 | - |
dc.identifier.wosid | 000310034900008 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.20, no.5, pp 487 - 491 | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 487 | - |
dc.citation.endPage | 491 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001699870 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | RESPONSIVE ELEMENT | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMOPROTECTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Rutaecarpine | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | Quinone reductase | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Hydrogen peroxide | - |
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