Adjunctive effect of intravitreal bevacizumab prior to lens-sparing vitrectomy in aggressive posterior retinopathy of prematurity: a case report
- Authors
- Sun, Hae Jung; Choi, Kyung Seek; Lee, Sung Jin
- Issue Date
- Sep-2012
- Publisher
- Springer Verlag
- Keywords
- Anti-VEGF; Bevacizumab; Lens-sparing vitrectomy; Retinopathy of prematurity
- Citation
- Japanese Journal of Ophthalmology, v.56, no.5, pp 476 - 480
- Pages
- 5
- Journal Title
- Japanese Journal of Ophthalmology
- Volume
- 56
- Number
- 5
- Start Page
- 476
- End Page
- 480
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14872
- DOI
- 10.1007/s10384-012-0141-8
- ISSN
- 0021-5155
1613-2246
- Abstract
- Intravitreal injection of bevacizumab in retinopathy of prematurity has shown satisfactory results without any systemic complications. However, increased fibrosis and tissue contraction are reported as adverse effects in some cases. A premature girl, born at 29 weeks + 4 days of gestation, had bilateral aggressive posterior retinopathy of prematurity (APROP) on her first screening at 3 weeks of age. She received extensive, near confluent, laser ablation of the avascular retina and off-label intravitreal bevacizumab (0.75 mg) injection OU. The right eye showed a slight regression, but a localized tractional membrane was noted OS. After another intravitreal bevacizumab injection in each eye, the left eye underwent lens-sparing vitrectomy (LSV) because of contraction of the proliferative membrane leading to a dome-shaped tractional retinal detachment (TRD). At 6-week follow-up, the left eye showed complete retinal reattachment. Both eyes showed prompt resolution of vascular engorgement with anterior progression of the peripheral retinal vasculature. Intravitreal bevacizumab is safe and effective as a treatment of APROP. In some cases tissue contraction may occur, but because TRD is localized to the posterior pole, effective LSV can be performed.
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