Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats
DC Field | Value | Language |
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dc.contributor.author | Nam, Sung Min | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Yoo, Dae Young | - |
dc.contributor.author | Kim, Woosuk | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.date.accessioned | 2021-08-12T02:47:33Z | - |
dc.date.available | 2021-08-12T02:47:33Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14985 | - |
dc.description.abstract | In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2,3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreactivity was not changed in CA3 region in all groups. These results suggest that STZ-induced type 1 diabetes transiently, but not permanently, decreased synaptic transmission and plasticity 3 weeks after STZ treatment in the dentate gyrus. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Maruzen Co., Ltd/Maruzen Kabushikikaisha | - |
dc.title | Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1292/jvms.12-0036 | - |
dc.identifier.scopusid | 2-s2.0-84867876804 | - |
dc.identifier.wosid | 000308845800003 | - |
dc.identifier.bibliographicCitation | Journal of Veterinary Medical Science, v.74, no.8, pp 977 - 982 | - |
dc.citation.title | Journal of Veterinary Medical Science | - |
dc.citation.volume | 74 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 977 | - |
dc.citation.endPage | 982 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | TREADMILL EXERCISE | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | streptozotocin | - |
dc.subject.keywordAuthor | type 1 diabetes | - |
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