In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Kim, Young-Hee | - |
dc.contributor.author | Seok, Su-Jin | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Hong, Sae-Yong | - |
dc.date.accessioned | 2021-08-12T02:48:04Z | - |
dc.date.available | 2021-08-12T02:48:04Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15022 | - |
dc.description.abstract | We investigated whether glyphosate influences the cellular toxicity of the surfactants TN-20 and LN-10 on the mouse fibroblast-like cells, alveolar epithelial cells, and a heart cell line. The cytotoxicity of TN-20 and LN-10 (0.4-100 mu M), in the presence or absence of glyphosate was determined by assessing membrane integrity. TN-20 toxicity was significantly lower in the presence of 50 mu M glyphosate for the fibroblast-like cell (6.25 mu M; 3.9% +/- 3.4% vs -4.8% +/- 0.7%), for the alveolar cells (0.78 mu M; 5.7% +/- 0.9% vs 0.1% +/- 0.6%), and for the heart cell line (25.0 mu M; 7.9% +/- 3.0% vs 19.4% +/- 0.7%) compared to that of TN-20 alone. The cellular toxicity of LN-10 towards the fibroblast-like cells was found to be increased in the presence of 50 mu M glyphosate when LN-10 concentrations of 50 mu M (31.3% +/- 3.9% vs 19.2% +/- 0.9%) and 100 mu M (62.1% +/- 3.4% vs 39.0% +/- 0.7%) were compared to that of LN-10 alone. These results suggest that the mixture toxicity may be a factor in glyphosate-surfactant toxicity in patients with acute glyphosate herbicide intoxication. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | In Vitro Cytotoxic Effect of Glyphosate Mixture Containing Surfactants | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2012.27.7.711 | - |
dc.identifier.scopusid | 2-s2.0-84866479436 | - |
dc.identifier.wosid | 000306433700001 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.27, no.7, pp 711 - 715 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 27 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 711 | - |
dc.citation.endPage | 715 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001681829 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | HERBICIDE | - |
dc.subject.keywordPlus | INTOXICATION | - |
dc.subject.keywordAuthor | Glyphosate | - |
dc.subject.keywordAuthor | Surfactants | - |
dc.subject.keywordAuthor | Complex Mixtures | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.subject.keywordAuthor | Herbicides | - |
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