WDR46 is a Genetic Risk Factor for Aspirin-Exacerbated Respiratory Disease in a Korean Population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pasaje, Charisse Flerida A. | - |
dc.contributor.author | Bae, Joon Seol | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.date.accessioned | 2021-08-12T02:48:09Z | - |
dc.date.available | 2021-08-12T02:48:09Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15028 | - |
dc.description.abstract | Purpose: The human WD repeat-containing protein 46 (WDR46, also known as C6orf11), located at the disease-relevant centromere side of the class II major histocompatibility complex region, is hypothesized to be associated with risk of aspirin-exacerbated respiratory disease (AERD) as well as a decline in forced expiratory volume in the first second (FEV1), an important diagnostic marker of asthma. Methods: To investigate the association between WDR46 and AERD, five single-nucleotide polymorphisms (SNPs) were genotyped in 93 AERD cases and 96 aspirin-tolerant asthma controls of Korean ethnicity. Three major haplotypes were inferred from pairwise comparison of the SNPs, and one was included in the association analysis. Differences in the frequency distribution of WDR46 SNPs and haplotype were analyzed using logistic and regression models via various modes of genetic inheritance. Results: Depending on the genetic model, the logistic and regression analyses revealed significant associations between rs463260, rs446735, rs455567, rs469064, and WDR46_ht2 and the risk of AERD (P=0.007-0.04, P-corr=0.01-0.04) and FEV1 decline after aspirin provocation (P=0.006-0.03, P-corr=0.01-0.03). Furthermore, functional analysis in silico showed that the G>A allele of rs463260 located in the 5' untranslated region potentially matched a nucleotide sequence within an upstream open reading frame of WDR46. Conclusions: These findings show for the first time that WDR46 is an important genetic marker of aspirin-induced airway inflammation and may be useful for formulating new disease-management strategies. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | WDR46 is a Genetic Risk Factor for Aspirin-Exacerbated Respiratory Disease in a Korean Population | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4168/aair.2012.4.4.199 | - |
dc.identifier.scopusid | 2-s2.0-84863876296 | - |
dc.identifier.wosid | 000305777400006 | - |
dc.identifier.bibliographicCitation | Allergy, Asthma & Immunology Research, v.4, no.4, pp 199 - 205 | - |
dc.citation.title | Allergy, Asthma & Immunology Research | - |
dc.citation.volume | 4 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 205 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001668507 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SINGLE-NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION ANALYSIS | - |
dc.subject.keywordPlus | INTOLERANT ASTHMA | - |
dc.subject.keywordPlus | HYPERSENSITIVITY | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | POWER | - |
dc.subject.keywordPlus | MHC | - |
dc.subject.keywordAuthor | Aspirin exacerbated respiratory disease | - |
dc.subject.keywordAuthor | WDR46 | - |
dc.subject.keywordAuthor | FEV1 | - |
dc.subject.keywordAuthor | haplotype | - |
dc.subject.keywordAuthor | single-nucleotide polymorphism | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.