Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sun Hwa | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Eom, Seon Ae | - |
dc.contributor.author | Jun, Se-Young | - |
dc.contributor.author | Park, Meeyoung | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Kwon, Hyung Joo | - |
dc.contributor.author | Kwon, Hyeok Yil | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Hwang, Hyun Sook | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-12T02:48:41Z | - |
dc.date.available | 2021-08-12T02:48:41Z | - |
dc.date.issued | 2012-06-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15053 | - |
dc.description.abstract | We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in animal models using a Tat-ANX1 protein. Topical application of the Tat-ANX1 protein markedly inhibited TPA-induced ear edema and expression levels of cyclooxygenase-2 (COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha). Also, application of Tat-ANX1 protein significantly inhibited nuclear translocation of nuclear factor-kappa B (NF-kappa B) and phosphorylation of p38 and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) in TPA-treated mice ears. The results indicate that Tat-ANX1 protein inhibits the inflammatory response by blocking NF-kappa B and MAPK activation in TPA-induced mice ears. Therefore, the Tat-ANX1 protein may be useful as a therapeutic agent against inflammatory skin diseases. [BMB Reports 2012; 45(6): 354-359] | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2012.45.6.036 | - |
dc.identifier.scopusid | 2-s2.0-84864385624 | - |
dc.identifier.wosid | 000306036500006 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.45, no.6, pp 354 - 359 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 45 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 354 | - |
dc.citation.endPage | 359 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001668712 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | Tat-ANX1 | - |
dc.subject.keywordAuthor | TPA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.