Association of Glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung-Kook | - |
dc.contributor.author | Lee, Soo Jeong | - |
dc.contributor.author | Joo, Jae Soon | - |
dc.contributor.author | Cho, Kwang-Sung | - |
dc.contributor.author | Kim, Nam Soo | - |
dc.contributor.author | Kim, Hak-Jae | - |
dc.date.accessioned | 2021-08-12T02:48:42Z | - |
dc.date.available | 2021-08-12T02:48:42Z | - |
dc.date.issued | 2012-06-30 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.issn | 2092-8467 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15054 | - |
dc.description.abstract | It is proposed that lead concentrations in the blood are related to intracellular glutathione and lead might be conjugated with glutathione non-enzymatically or enzymatically via glutathione S-transferase (GST). Essential hypertension is a complex, multifactorial and polygenic disease in which the underlying genetic components remain unknown. This study was aimed to investigate GST-mu1 (GSTM1) and GST-theta1 (GSTT1) gene polymorphisms in lead-exposed workers and their relationship with blood lead levels and lead-related hypertension. To address the possible association, GSTM1 and GSTT1 (homozygous deletion vs. non-deleted) polymorphisms in 755 lead-exposed male workers were analyzed. GSTM1 and GSTT1 polymorphisms were determined using a Multiplex PCR. We observed significant association in positive alleles of GSTT1 (OR = 1.593, 95% CI=.1..157-2.194). However, no significant association in GSTM1 was observed with lead-related hypertension. For combined analysis with GSTM1 and GSTT1 both positive type (+/+) and GSTT1 positive (-/+) group showed significant differences between groups. These data suggest that the GSTT1 positive type polymorphism might be associated with lead-related hypertension in the lead-exposed male workers. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한독성 유전단백체 학회 | - |
dc.title | Association of Glutathione S-transferase genes (GSTM1 and GSTT1) polymorphisms with hypertension in lead-exposed workers | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s13273-012-0025-5 | - |
dc.identifier.scopusid | 2-s2.0-84866084173 | - |
dc.identifier.wosid | 000305863500012 | - |
dc.identifier.bibliographicCitation | Molecular & Cellular Toxicology, v.8, no.2, pp 203 - 208 | - |
dc.citation.title | Molecular & Cellular Toxicology | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 208 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | REDUCTASE | - |
dc.subject.keywordPlus | GENOMICS | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordAuthor | Lead | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Glutathione S-transferases (GSTs) | - |
dc.subject.keywordAuthor | GSTT1 | - |
dc.subject.keywordAuthor | GSTM1 | - |
dc.subject.keywordAuthor | Polymorphism | - |
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