Allyl isothiocyanate suppresses lipopolysaccharide-induced expression of inducible nitric oxide synthase, but not induced expression of cyclooxygenase-2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soo-Jung | - |
dc.contributor.author | Park, Hye-Jeong | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-12T03:24:20Z | - |
dc.date.available | 2021-08-12T03:24:20Z | - |
dc.date.issued | 2012-06-30 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.issn | 2092-8467 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15056 | - |
dc.description.abstract | The pathophysiological processes of inflammation are involved in numerous diseases including cancer. Dysregulated activation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Allyl isothiocyanate (AITC), which is present in many common cruciferous vegetables, has been used to treat many chronic diseases. The present study investigated the effect of AITC on lipopolysaccharide (LPS)-induced iNOS and COX-2 expression in marine macrophages. AITC suppressed LPS-induced iNOS expression, but did not suppress LPS-induced COX-2 expression, suggesting that AITC has a specific anti-inflammatory mechanism. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한독성 유전단백체 학회 | - |
dc.title | Allyl isothiocyanate suppresses lipopolysaccharide-induced expression of inducible nitric oxide synthase, but not induced expression of cyclooxygenase-2 | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s13273-012-0018-4 | - |
dc.identifier.scopusid | 2-s2.0-84866073761 | - |
dc.identifier.wosid | 000305863500005 | - |
dc.identifier.bibliographicCitation | Molecular & Cellular Toxicology, v.8, no.2, pp 149 - 154 | - |
dc.citation.title | Molecular & Cellular Toxicology | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 154 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | TBK1 | - |
dc.subject.keywordPlus | PHYTOCHEMICALS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordAuthor | Allyl isothiocyanate | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
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