Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hoon Jae | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Woo, Su Jung | - |
dc.contributor.author | Kim, Hye Ri | - |
dc.contributor.author | Kim, So Mi | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Park, Meeyoung | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Kwon, Oh-Shin | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-12T03:26:45Z | - |
dc.date.available | 2021-08-12T03:26:45Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15234 | - |
dc.description.abstract | Parkinson's disease (PD) is a well known neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compact (SN). Although the exact mechanism remains unclear, oxidative stress plays a critical role in the pathogenesis of PD. DJ-1 is a multifunctional protein, a potent antioxidant and chaperone, the loss of function of which is linked to the autosomal recessive early onset of PD. Therefore, we investigated the protective effects of DJ-1 protein against SH-SY5Y cells and in a PD mouse model using a cell permeable Tat-DJ-1 protein. Tat-DJ-1 protein rapidly transduced into the cells and showed a protective effect on 6-hydroxydopamine (6-OHDA)-induced neuronal cell death by reducing the reactive oxygen species (ROS). In addition, we found that Tat-DJ-1 protein protects against dopaminergic neuronal cell death in 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP)-induced PD mouse models. These results suggest that Tat-DJ-1 protein provides a potential therapeutic strategy for against ROS related human diseases including PD. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국분자세포생물학회 | - |
dc.title | Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s10059-012-2255-8 | - |
dc.identifier.scopusid | 2-s2.0-84863499045 | - |
dc.identifier.wosid | 000304176600007 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, v.33, no.5, pp 471 - 478 | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 471 | - |
dc.citation.endPage | 478 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001660805 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | EFFICIENTLY PROTECTS | - |
dc.subject.keywordPlus | DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | DJ-1 | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DISMUTASE | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MPTP | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | Parkinson disease | - |
dc.subject.keywordAuthor | protein transduction | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Tat-DJ-1 | - |
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