Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Hwang, Hyun Sook | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Sheen, Seung Hoon | - |
dc.contributor.author | Heo, Dong Hwa | - |
dc.contributor.author | Hwang, Gyojun | - |
dc.contributor.author | Kang, Suk Hyung | - |
dc.contributor.author | Kweon, HaeYong | - |
dc.contributor.author | Jo, You-Young | - |
dc.contributor.author | Kang, Seok Woo | - |
dc.contributor.author | Lee, Kwang-Gill | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Cho, Yong-Jun | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-12T03:27:32Z | - |
dc.date.available | 2021-08-12T03:27:32Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15297 | - |
dc.description.abstract | Silk fibroin (SF) peptide has been traditionally used as a treatment for flatulence, spasms, and phlegm. In this study, we examined whether SF peptide enhanced the anti-inflammatory effect of PEP-1-FK506 binding protein (PEP-1-FK506BP) through comparing the anti-inflammatory activities of SF peptide and/or PEP-1-FK506BP. In the presence or absence of SF peptide, transduction levels of PEP-1-FK506BP into HaCaT cells and mice skin and anti-inflammatory activities of PEP-1-FK506BP were identified by Western blot and histological analyses. SF peptide alone effectively reduced both mice ear edema and the elevated levels of cyclooxygenase-2, interleukin-6 and -1 beta, and tumor necrosis factor-alpha, showing similar anti-inflammatory effect to that of PEP-1-FK506BP. Furthermore, co-treatment with SF peptide and PEP-1-FK506BP exhibited more enhanced anti-inflammatory effects than the samples treated with SF peptides or PEP-1-FK506BP alone, suggesting the possibility that SF peptide and PEP-1-FK506BP might interact with each other. Moreover, the transduction data demonstrated that SF peptide did not affect the transduction of PEP-1-FK506BP into HaCaT cells and mice skin, indicating that the improvement of anti-inflammatory effect of PEP-1-FK506BP was not caused by enhanced transduction of PEP-1-FK506BP. Thus, these results suggest the possibility that co-treatment with SF peptide and PEP-1-FK506BP may be exploited as a useful therapy for various inflammation-related diseases. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4014/jmb.1111.11024 | - |
dc.identifier.scopusid | 2-s2.0-84860152557 | - |
dc.identifier.wosid | 000303374000008 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, v.22, no.4, pp 494 - 500 | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 494 | - |
dc.citation.endPage | 500 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001654093 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | TRANSDUCTION EFFICIENCY | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | 12-O-TETRADECANOYLPHORBOL-13-ACETATE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PHOSPHATASE | - |
dc.subject.keywordPlus | TECHNOLOGY | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | PEP-1-FK506BP | - |
dc.subject.keywordAuthor | protein transduction | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | silk fibroin peptide | - |
dc.subject.keywordAuthor | TPA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.