Quantitative in-line monitoring of solvent-mediated polymorphic transformation of sulfamerazine by near-infrared spectroscopy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min-Jeong | - |
dc.contributor.author | Seo, Da-Young | - |
dc.contributor.author | Wang, In-Chun | - |
dc.contributor.author | Chun, Nan-Hee | - |
dc.contributor.author | Lee, Hea-Eun | - |
dc.contributor.author | Jeong, Myung-Yung | - |
dc.contributor.author | Kim, Woo-Sik | - |
dc.contributor.author | Choi, Guang J. | - |
dc.date.accessioned | 2021-08-12T03:27:45Z | - |
dc.date.available | 2021-08-12T03:27:45Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0022-3549 | - |
dc.identifier.issn | 1520-6017 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15308 | - |
dc.description.abstract | The in-line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well-known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent-mediated polymorphic transformation (SMPT). The primary purpose of this study is to monitor the polymorphic transformation through in-line near-infrared (NIR) measurements and concurrently interpret the whole process quantitatively with off-line characterizations. Samples taken at every hour during SMPT were analyzed by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). NIR spectra in the range of 75004900 cm-1 were taken into account for multivariate analysis, which included partial least square (PLS) regression and principal component analysis (PCA). In brief, the form II content was estimated very accurately and reproducibly during the SMPT process not only by XRD but also by the DSC measurements. In addition, the form II content values were predicted very accurately by separate experiments at two designated time points. In a separate study, it was demonstrated that PCA could be employed to explain a complicated process such as SMPT mechanistically by several stages. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:15781586, 2012 | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Quantitative in-line monitoring of solvent-mediated polymorphic transformation of sulfamerazine by near-infrared spectroscopy | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jps.23042 | - |
dc.identifier.wosid | 000300720200022 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical Sciences, v.101, no.4, pp 1578 - 1586 | - |
dc.citation.title | Journal of Pharmaceutical Sciences | - |
dc.citation.volume | 101 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1578 | - |
dc.citation.endPage | 1586 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PHASE-TRANSFORMATION | - |
dc.subject.keywordPlus | RAMAN-SPECTROSCOPY | - |
dc.subject.keywordPlus | NIR SPECTROSCOPY | - |
dc.subject.keywordPlus | CRYSTALLIZATION | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | STATE | - |
dc.subject.keywordAuthor | sulfamerazine | - |
dc.subject.keywordAuthor | solvent-mediated polymorphic transformation | - |
dc.subject.keywordAuthor | in-line monitoring | - |
dc.subject.keywordAuthor | Near-infrared spectroscopy (NIR) | - |
dc.subject.keywordAuthor | X-ray diffractometry (XRD) | - |
dc.subject.keywordAuthor | Calorimetry (DSC) | - |
dc.subject.keywordAuthor | Partial least squares (PLS) | - |
dc.subject.keywordAuthor | Principal component analysis (PCA) | - |
dc.subject.keywordAuthor | polymorph | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.