Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Sae Hwan | - |
dc.contributor.author | Chung, Young-Hwa | - |
dc.contributor.author | Kim, Jeong A. | - |
dc.contributor.author | Lee, Danbi | - |
dc.contributor.author | Jin, Young-Joo | - |
dc.contributor.author | Shim, Ju Hyun | - |
dc.contributor.author | Jang, Myoung-Kuk | - |
dc.contributor.author | Cho, Eun-Young | - |
dc.contributor.author | Shin, Eun-Soon | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Park, Neung Hwa | - |
dc.contributor.author | Yu, Eunsil | - |
dc.contributor.author | Lee, Young Joo | - |
dc.date.accessioned | 2021-08-12T03:28:15Z | - |
dc.date.available | 2021-08-12T03:28:15Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.issn | 1478-3231 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15345 | - |
dc.description.abstract | Backgrounds/Aims: Metastatic tumour antigen 1 (MTA1) promotes angiogenesis by stabilizing hypoxia-inducible factor-1 alpha (HIF-1 alpha), which is closely associated with frequent postoperative recurrence and poor survival in patients with HCC. In this study, we determined single nucleotide polymorphisms (SNPs) in angiogenesis-related genes that are associated with MTA1 overexpression in HCC tissues. Methods: A total of 376 patients with HCC who had received curative surgical resection or liver transplantation were enrolled (312/21/43; HBV/HCV/NBNC). MTA1 expression was determined via immunohistochemistry. Thirty-three common SNPs sites (frequency -5%) in the angiogenic protein gene that are closely connected to one another were selected, including MTA1, VEGF, HIF-1 alpha, FGF-2, and IGF-II. Results: Expression of MTA1 was detected in 120 HCC tissues (31%). An A allele at position IVS4-81G/A of the MTA1 gene (P = 0.016) and the TT genotype at position + 12916C of the VEGF gene (P = 0.023) were significantly associated with MTA1 overexpression. However, the TT genotype at position -13021C (P = 0.011) and the haplotypes CT-CT (-11228C; -13021C) of the IGF-II gene (P-cor = 0.033) were more common in patients with MTA1-negative HCC. Using multivariate analysis, the A allele at IVS4-81G/A in MTA1 gene (P = 0.015) and a T allele (TT+ CT genotype) at -13021C in IGF-II (P = 0.002) were independent risk factors in HCC recurrence after curative surgical resection. Conclusions: The genetic polymorphisms IVS4-81G/A in MTA1 and + 12916C in VEGF genes were correlated with MTA1 overexpression. The SNPs in MTA1 and IGF-II genes may be important risk factors for the recurrence of HCC. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1478-3231.2011.02648.x | - |
dc.identifier.scopusid | 2-s2.0-84863071925 | - |
dc.identifier.wosid | 000300006500013 | - |
dc.identifier.bibliographicCitation | Liver International, v.32, no.3, pp 457 - 466 | - |
dc.citation.title | Liver International | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 466 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | FACTOR GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | HEPATITIS-B | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | PROTEIN-1 | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | MTA1 | - |
dc.subject.keywordAuthor | polymorphism | - |
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