Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Park, Byung-Lae | - |
dc.contributor.author | Pasaje, Charisse Flerida A. | - |
dc.contributor.author | Bae, Joon Seol | - |
dc.contributor.author | Park, Jong Sook | - |
dc.contributor.author | Park, Sung Woo | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Choi, Jae-Sung | - |
dc.contributor.author | Kim, Yong-Hoon | - |
dc.contributor.author | Kim, Mi-Kyeong | - |
dc.contributor.author | Choi, Inseon S. | - |
dc.contributor.author | Cho, Sang Heon | - |
dc.contributor.author | Choi, Byoung Whui | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.date.accessioned | 2021-08-12T03:28:18Z | - |
dc.date.available | 2021-08-12T03:28:18Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.issn | 1573-4978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15347 | - |
dc.description.abstract | Aspirin exacerbated respiratory disease (AERD) is a clinical condition characterized by severe decline in forced expiratory volume in one second (FEV1) following the ingestion of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. The exacerbated inflammatory response in Fancc-deficient mice has been reported to be associated with hemopoietic responses that are also related to AERD pathogenesis. To investigate associations of FANCC polymorphisms with AERD and related phenotypes, this study genotyped 25 common single nucleotide polymorphisms (SNPs) in a total of 592 Korean asthmatics including 163 AERD and 429 aspirin-tolerant asthma (ATA) subjects. Logistic analysis revealed that genetic polymorphisms of the FANCC gene might not be directly related to AERD development and nasal polyposis (P > 0.05). However, the FEV1 decline by aspirin provocation showed significant associations with FANCC polymorphisms (P = 0.006-0.04) and a haplotype (unique to rs4647416G > A, P = 0.01 under co-dominant, P = 0.006 under recessive model). In silico analysis showed that the "A" allele of rs4647376C > A, which was more prevalent in AERD than in ATA, could act as a potential branch point (BP) site for alternative splicing (BP score = 4.16). Although replications in independent cohorts and further functional evaluations are still needed, our preliminary findings suggest that FANCC polymorphisms might be associated with the obstructive symptoms in allergic diseases. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.title | Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s11033-011-0989-6 | - |
dc.identifier.scopusid | 2-s2.0-84863840545 | - |
dc.identifier.wosid | 000301107800037 | - |
dc.identifier.bibliographicCitation | Molecular Biology Reports, v.39, no.3, pp 2385 - 2394 | - |
dc.citation.title | Molecular Biology Reports | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 2385 | - |
dc.citation.endPage | 2394 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | INTOLERANT ASTHMA | - |
dc.subject.keywordPlus | CYSTIC-FIBROSIS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | SENSITIVE PATIENTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHALLENGE | - |
dc.subject.keywordPlus | HAPLOTYPE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Aspirin exacerbated respiratory disease (AERD) | - |
dc.subject.keywordAuthor | FANCC | - |
dc.subject.keywordAuthor | Single nucleotide polymorphism | - |
dc.subject.keywordAuthor | Haplotype | - |
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