STAGE-TO-STAGE COMPARISON OF PREOPERATIVE AND POSTOPERATIVE CHEMORADIOTHERAPY FOR T3 MID OR DISTAL RECTAL CANCER
DC Field | Value | Language |
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dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Park, Ji Won | - |
dc.contributor.author | Choi, Hyo Seong | - |
dc.contributor.author | Oh, Jae Hwan | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Chang, Hee Jin | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Sohn, Dae Kyung | - |
dc.date.accessioned | 2021-08-12T03:44:26Z | - |
dc.date.available | 2021-08-12T03:44:26Z | - |
dc.date.issued | 2012-02-01 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.issn | 1879-355X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15361 | - |
dc.description.abstract | Purpose: To investigate, in a comparative analysis, the prognostic implications of postchemoradiotherapy (post-CRT) pathologic stage (ypStage) vs. postoperative pathologic stage (pStage) in rectal cancer. Methods and Materials: Between May 2001 and December 2006, 487 patients with T3 mid or distal rectal cancer were analyzed retrospectively. Concurrent CRT was administered preoperatively (n = 364, 74.7%) or postoperatively (n = 123, 25.3%). The radiation dose was 50.4 Gy in 28 fractions. All patients underwent a total mesorectal excision and received adjuvant chemotherapy. Disease-free survival (DES) was estimated using the Kaplan-Meier method. Differences in DFS, stratified by ypStage and pStage, were compared using the log rank test. Results: For surviving patients, the median follow-up period was 68 months (range, 12-105 months). The 5-year local recurrence-free survival rate was not different, at 95.3% and 92.1% in preoperative and postoperative CRT groups, respectively (p = 0.402), but the 5-year distant metastasis-free survival rate was significantly different, at 81.6% (preoperative CRT) vs. 65.4% (postoperative CRT; p = 0.001). The 5-year DFS rate of 78.8% in the preoperative CRT group was significantly better than the 63.0% rate in the postoperative CRT group (p = 0.002). Post-CRT pathologic Stage 0-I occurred in 42.6% (155 of 364) of the patients with preoperative CRT. The 5 year DFS rates were 90.2% (ypStage 0-I), 83.5% (ypStage II), 77.3% (pStage H), 58.6% (ypStage HI), and 54.7% (pStage III). The DES rate of ypStage 0-I was significantly better than that of ypStage H or pStage II. Post-CRT pathologic Stage H and III had similar DFS, compared with pStage II and III, respectively. Conclusions: Disease-free survival predicted by each ypStage was similar to that predicted by the respective pStage. Improved DFS with preoperative vs. postoperative CRT was associated with the ypStage 0 I group that showed a similarly favorable outcome to pStage I rectal cancer. (C) 2012 Elsevier Inc. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | STAGE-TO-STAGE COMPARISON OF PREOPERATIVE AND POSTOPERATIVE CHEMORADIOTHERAPY FOR T3 MID OR DISTAL RECTAL CANCER | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ijrobp.2010.10.079 | - |
dc.identifier.scopusid | 2-s2.0-84862959551 | - |
dc.identifier.wosid | 000299239900060 | - |
dc.identifier.bibliographicCitation | International Journal of Radiation Oncology Biology Physics, v.82, no.2, pp 856 - 862 | - |
dc.citation.title | International Journal of Radiation Oncology Biology Physics | - |
dc.citation.volume | 82 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 856 | - |
dc.citation.endPage | 862 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | DISEASE-FREE SURVIVAL | - |
dc.subject.keywordPlus | LONG-TERM ANALYSIS | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | ABDOMINOPERINEAL RESECTION | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | COMPLETE RESPONSE | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | ADJUVANT | - |
dc.subject.keywordAuthor | ypStage | - |
dc.subject.keywordAuthor | pStage | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Chemoradiotherapy | - |
dc.subject.keywordAuthor | Downstaging | - |
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