Optimal Duration of Proton Pump Inhibitor in the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Retrospective Analysis and Prospective Validation Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Suck-Ho | - |
dc.contributor.author | Lee, Chang Kyun | - |
dc.contributor.author | Chung, Il-Kwun | - |
dc.contributor.author | Shim, Yun Suk | - |
dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Lee, Sae Hwan | - |
dc.contributor.author | Kim, Hong-Soo | - |
dc.contributor.author | Park, Sang-Heum | - |
dc.contributor.author | Kim, Sun-Joo | - |
dc.date.accessioned | 2021-08-12T03:45:16Z | - |
dc.date.available | 2021-08-12T03:45:16Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15411 | - |
dc.description.abstract | The optimal duration of proton pump inhibitor (PPI) use in the treatment of endoscopic submucosal dissection (ESD)-induced ulcers has not been well defined. The aim of study was to determine the optimal duration of PPI treatment for ESD-induced gastric ulcers. A total of 333 patients who underwent ESD were included in this retrospective analysis and prospective randomized validation. Medical records and endoscopic images for the 221 patients in our ESD-database were reviewed retrospectively. Based on the results of the retrospective analysis, 112 patients with ESD-induced ulcers over 40 mm were randomly assigned to two groups (4- or 8-week course of Lansoprazole 30 mg). Main outcome measurements were to assess the healing-related factors of post-ESD ulcers (retrospective analysis) and to compare complete mucosal healing rate in large (a parts per thousand yen40 mm) ESD-induced ulcers according to the duration of PPI treatment (prospective validation). Multivariate logistic regression from a retrospective analysis showed that a duration of PPI treatment < 8 weeks and a post-ESD ulcer a parts per thousand yen40 mm in size were associated with incomplete healing. In a prospective validation, the rate of complete healing in the 8-week PPI group was significantly higher than that of the 4-week PPI group for a large (a parts per thousand yen40 mm) ESD-induced ulcer at 8 weeks follow-up (83.3 vs. 42.6%, P < 0.01). The optimal duration of PPI treatment varies based on the initial ulcer size. Patients with an ESD-induced ulcer over 40 mm should be treated with an 8-week course of PPIs. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Optimal Duration of Proton Pump Inhibitor in the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Retrospective Analysis and Prospective Validation Study | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10620-011-1941-2 | - |
dc.identifier.scopusid | 2-s2.0-84856730485 | - |
dc.identifier.wosid | 000299487500024 | - |
dc.identifier.bibliographicCitation | Digestive Diseases and Sciences, v.57, no.2, pp 429 - 434 | - |
dc.citation.title | Digestive Diseases and Sciences | - |
dc.citation.volume | 57 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 429 | - |
dc.citation.endPage | 434 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | EARLY GASTRIC-CANCER | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | MUCOSAL RESECTION | - |
dc.subject.keywordPlus | OMEPRAZOLE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Endoscopic submucosal dissection | - |
dc.subject.keywordAuthor | Stomach | - |
dc.subject.keywordAuthor | Ulcer | - |
dc.subject.keywordAuthor | Proton pump inhibitors | - |
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