Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease
DC Field | Value | Language |
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dc.contributor.author | Ahn, Joong Kyong | - |
dc.contributor.author | Cha, Hoon-Suk | - |
dc.contributor.author | Lee, Jaejoon | - |
dc.contributor.author | Jeon, Chan Hong | - |
dc.contributor.author | Koh, Eun-Mi | - |
dc.date.accessioned | 2021-08-12T03:45:57Z | - |
dc.date.available | 2021-08-12T03:45:57Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15459 | - |
dc.description.abstract | Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding alpha-defensin-1 in samples from Korean individuals with Behcet's disease (BD) compared to healthy controls (HC). We recruited 55 BD patients and 35 HC. A duplex Taqman (R) real-time PCR assay was used to assess CN. Most samples (31.1%) had a CN of 5 with a mean CN of 5.4 +/- 0.2. There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to intestinal involvement in BD. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2012.27.1.107 | - |
dc.identifier.scopusid | 2-s2.0-84863175095 | - |
dc.identifier.wosid | 000299039200021 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.27, no.1, pp 107 - 109 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 107 | - |
dc.citation.endPage | 109 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001625105 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ALPHA-DEFENSIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | TRISOMY-8 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Behcet Syndrome | - |
dc.subject.keywordAuthor | Copy Number Variation | - |
dc.subject.keywordAuthor | DEFA1 Gene | - |
dc.subject.keywordAuthor | Intestinal Involvement | - |
dc.subject.keywordAuthor | Korean | - |
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