Serial Measurements of Off-Thyroxine Serum TSH and Thyroglobulin Levels to Predict Local and/or Systemic Metastasis of Papillary Thyroid Cancer after Total Thyroidectomy
DC Field | Value | Language |
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dc.contributor.author | 이정원 | - |
dc.contributor.author | 김선형 | - |
dc.contributor.author | 이상아 | - |
dc.contributor.author | 고관표 | - |
dc.contributor.author | 이상미 | - |
dc.contributor.author | 이대호 | - |
dc.date.accessioned | 2021-08-12T03:47:36Z | - |
dc.date.available | 2021-08-12T03:47:36Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2384-3799 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15582 | - |
dc.description.abstract | Background and Objectives: Off-thyroxine serum thyroglobulin (Tg) level is important to predict metastatic disease (MD) in papillary thyroid cancer (PTC); however, it is unclear whether a single off-thyroxine Tg level is sufficient for predicting MD. In this study, we determined whether serial measurement of off-thyroxine serum Tg level can predict metastasis in PTC patients after total thyroidectomy. Materials and Methods: We enrolled 140 PTC patients in whom serum thyroid-stimulating hormone (TSH) and Tg levels were measured 7 days before radio-iodine (RAI) treatment (TSHA and TgA) and on the day of RAI treatment (TSHB and TgB) with withholding L-thyroxine for 4 weeks before RAI treatment. The values of TSHinc (TSHB-TSHA) and Tginc (TgB-TgA), Tgratio (TgB/TgA),Tginc/TSHinc and Tgratio/TSHinc were calculated. Tginc/TSHinc and Tgratio/TSHinc were tested if those parameters can predict MD in patients with TSHA>30 μIU/mL and TgA<10 ng/mL. Results: Forty-four patients had MD and 96had no evidence of MD (non-MD). MD group showed higher levels of TgA, TgB, Tginc, Tginc/TSHinc and Tgratio/TSHinc compared with non-MD group. A significant correlation was found between TSHinc and Tgratio (r=0.669) in MD group. In 43 patients with TSHA>30 μIU/mL and TgA<10 ng/mL (MD, 9; non-MD, 34), both Tginc/TSHinc (100%)and Tgratio/TSHinc (89%) had higher sensitivities for predicting MD than TgB (78%). Conclusion: With the increment in serum Tg corrected for the increment in serum TSH, serial measurements of off-thyroxine serum TSH and Tg levels can help predict PTC metastasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한갑상선학회 | - |
dc.title | Serial Measurements of Off-Thyroxine Serum TSH and Thyroglobulin Levels to Predict Local and/or Systemic Metastasis of Papillary Thyroid Cancer after Total Thyroidectomy | - |
dc.title.alternative | Serial Measurements of Off-Thyroxine Serum TSH and Thyroglobulin Levels to Predict Local and/or Systemic Metastasis of Papillary Thyroid Cancer after Total Thyroidectomy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이상미 | - |
dc.identifier.bibliographicCitation | International Journal of Thyroidology, v.5, no.2, pp.148 - 156 | - |
dc.relation.isPartOf | International Journal of Thyroidology | - |
dc.citation.title | International Journal of Thyroidology | - |
dc.citation.volume | 5 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 148 | - |
dc.citation.endPage | 156 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001741376 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | Thyroid cancer | - |
dc.subject.keywordAuthor | Thyroglobulin | - |
dc.subject.keywordAuthor | TSH | - |
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