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The Inhibitory Effect of Phytochemicals on the Oxidative DNA Damage in Lymphocytes by ChrysotileThe Inhibitory Effect of Phytochemicals on the Oxidative DNA Damage in Lymphocytes by Chrysotile
- Other Titles
- The Inhibitory Effect of Phytochemicals on the Oxidative DNA Damage in Lymphocytes by Chrysotile
- Authors
- A-Reum Ryu; 김점지; 이미영
- Issue Date
- 2012
- Publisher
- 한국응용생명화학회
- Keywords
- asbestos; lipid peroxidation; phytochemicals; reactive oxygen speices
- Citation
- Journal of Applied Biological Chemistry, v.55, no.3, pp.179 - 184
- Journal Title
- Journal of Applied Biological Chemistry
- Volume
- 55
- Number
- 3
- Start Page
- 179
- End Page
- 184
- ISSN
- 1976-0442
- Abstract
- We investigated the cytotoxicity and oxidative DNA damage by chrysotile, one of the asbestos, in this investigation. Chrysotile enhanced malondialdehyde (MDA) levels and intracellular reactive oxygen speices generation in human airway epithelial cells. Furthermore, asbestos-induced oxidative DNA damage in lymphocytes was evaluated by single cell gel electrophoresis and quantified as DNA tail moment. Notably, phytochemicals such as curcumin, berberine, and sulforaphane presented inhibitory effect on the asbestos-induced oxidative DNA damage in lymphocytes.
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Related Researcher
- Lee, Mi young
- College of Medical Sciences (Department of Medical Biotechnology)