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Dieldrin에 의한 DNA와 세포 손상에 대한 오가피 추출물의 억제효과Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin
- Other Titles
- Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin
- Issue Date
- 2012
- Publisher
- 한국약용작물학회
- Keywords
- Dieldrin; Acanthopanax; Cell damage; DNA damage
- Citation
- 한국약용작물학회지, v.20, no.4, pp.245 - 250
- Journal Title
- 한국약용작물학회지
- Volume
- 20
- Number
- 4
- Start Page
- 245
- End Page
- 250
- ISSN
- 1225-9306
- Abstract
- Dieldrin, one of the organochlorine pesticides (OCPs), induced the damages in neuroblastoma cells and DNA damages in lymphocytes. The ethanol extracts of A. sessiliflorus leaves were examined for the suppressive effects on the dieldrin-induced cell damages. Moreover, the extract was used to test whether it might inhibit the oxidative DNA damage of lymphocytes using Comet assay. The cell and DNA damage by dieldrin were suppressed in vitro upon treating A. sessiliflorus extract. This result suggests that A. sessiliflorus extract might be useful to reduce dieldrin toxicity.
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Related Researcher
- Lee, Mi young
- College of Medical Sciences (Department of Medical Biotechnology)