The Clinical Characteristics, Therapeutic Outcome and Prognostic Factors for Invasive Pulmonary Aspergillosis: A Single-Center Experience and Review of the Literature
DC Field | Value | Language |
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dc.contributor.author | 박세윤 | - |
dc.contributor.author | 이은정 | - |
dc.contributor.author | 김태형 | - |
dc.contributor.author | 추은주 | - |
dc.contributor.author | 전민혁 | - |
dc.contributor.author | 공민규 | - |
dc.contributor.author | 주진우 | - |
dc.date.accessioned | 2021-08-12T04:27:23Z | - |
dc.date.available | 2021-08-12T04:27:23Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-4709 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/15909 | - |
dc.description.abstract | Background: Despite advances in microbiological diagnosis and effective antifungal treatment,invasive pulmonary aspergillosis (IPA) is a still major cause of mortality in immunocompromised patients. Objective: The aim of this study is to analyze clinical characteristics, treatment outcome and prognostic factors for IPA. Methods: Between May 2003 and March 2011, we retrospectively studied all patients with IPA in our facility. Results: A total 37 cases were identified. Hematologic malignancies were the leading underlying disease for 27 (27/37, 73.0%) patients. Neutropenic period between the onset of neutropenia and the diagnosis of IPA was 15.0 days. The most common symptom was fever (35/37, 94.6%). The principal findings of chest computed tomography (CT) were segmental or air space consolidation (17/37, 45.9%)followed by halo sign (13/37, 35.1%), and ground-glass attenuation (11/37, 29.7%). Amphotericin B was the initial treatment for 36 (36/37, 97.3%) patients. Voriconazole was subsequently substituted for Amphotericin B in 25 (35/36, 97.2%) patients. The 30-day mortality rate was 24.3% (9/37). The 30-day mortality rate was associated with a failure to recover from neutropenia (p=0.048) or persistent fever during treatment (p=0.003). Two patients were lost to follow-up. Overall mortality was 62.9% (22/35). Conclusion: IPA remains a serious condition with failure to recover from neutropenia or persistent fever during treatment associated with a high 30-day mortality rate. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의진균학회 | - |
dc.title | The Clinical Characteristics, Therapeutic Outcome and Prognostic Factors for Invasive Pulmonary Aspergillosis: A Single-Center Experience and Review of the Literature | - |
dc.title.alternative | The Clinical Characteristics, Therapeutic Outcome and Prognostic Factors for Invasive Pulmonary Aspergillosis: A Single-Center Experience and Review of the Literature | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이은정 | - |
dc.contributor.affiliatedAuthor | 김태형 | - |
dc.contributor.affiliatedAuthor | 추은주 | - |
dc.contributor.affiliatedAuthor | 전민혁 | - |
dc.identifier.doi | 10.17966/jmi.2012.17.1.17 | - |
dc.identifier.bibliographicCitation | 대한의진균학회지, v.17, no.1, pp.17 - 24 | - |
dc.relation.isPartOf | 대한의진균학회지 | - |
dc.citation.title | 대한의진균학회지 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 24 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001651215 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Invasive pulmonary aspergillosis | - |
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