Surfactant volume is an essential element in human toxicity in acute glyphosate herbicide intoxication
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seok, Su-Jin | - |
dc.contributor.author | Park, Jae-Seok | - |
dc.contributor.author | Hong, Joong-Rock | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Yang, Jong-Oh | - |
dc.contributor.author | Lee, Eun-Young | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Hong, Sae-Yong | - |
dc.date.accessioned | 2021-08-12T04:45:57Z | - |
dc.date.available | 2021-08-12T04:45:57Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 1556-3650 | - |
dc.identifier.issn | 1556-9519 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16079 | - |
dc.description.abstract | Background: Glyphosate, one of the most commonly used herbicides worldwide, has been considered as minimally toxic to humans. However, clinical toxicologists occasionally encounter cases of severe systemic toxicity. The purpose of this study was to determine the effect of glyphosate-surfactants ("glyphosate-surfactant toxicity") in patients with acute glyphosate intoxication. Methods: In all, 107 patients (69 men and 38 women, aged 52.3 +/- 15.5 years) with acute glyphosate intoxication were enrolled in this study. From their medical records, we identified the formulation of ingested glyphosate products and derived clinical parameters, which focused on clinical outcome, admission days, duration in the intensive care unit, development of respiratory failure, cardiovascular deterioration, renal failure, altered mental status, and convulsions. The effect of surfactants on clinical complications was also assessed. Results: For surfactant ingestion volumes of 8 mL, the incidence of clinical complications was (in rank order) as follows: hypotension, 47.1%; mental deterioration, 38.6%; respiratory failure, 30.0%; acute kidney injury, 17.1%; and arrhythmia, 10.0%. These complications were influenced by the volume of surfactant and not the type of surfactant-ingredient in the herbicide product. Two patients died of refractory shock, metabolic acidosis, and respiratory failure. However, the final clinical outcomes of the surviving patients were benign, and cardiovascular, respiratory, kidney, and mental functions were fully restored to normal levels. Conclusions: Our results indicate that treatment of patients with acute glyphosate herbicide intoxication should take into account the volume and not the type of surfactants in herbicide formulations. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor & Francis | - |
dc.title | Surfactant volume is an essential element in human toxicity in acute glyphosate herbicide intoxication | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3109/15563650.2011.626422 | - |
dc.identifier.scopusid | 2-s2.0-83755178984 | - |
dc.identifier.wosid | 000298056900004 | - |
dc.identifier.bibliographicCitation | Clinical Toxicology, v.49, no.10, pp 892 - 899 | - |
dc.citation.title | Clinical Toxicology | - |
dc.citation.volume | 49 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 892 | - |
dc.citation.endPage | 899 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | SHIKIMATE PATHWAY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SYNTHASE | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordAuthor | Glyphosate | - |
dc.subject.keywordAuthor | Surfactants | - |
dc.subject.keywordAuthor | Acute intoxication | - |
dc.subject.keywordAuthor | Polyoxyethylene tallow amine | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.